Hematoporphyrin Dihydrochloride 血卟啉二盐酸盐
CAS 17696-69-4 MFCD00013470
化学结构图
SMILES: Cl.Cl.CC1C(C(C)O)=C2C=C3N=C(C=C4NC(=CC5=NC(=CC=1N2)C(C)=C5CCC(O)=O)C(CCC(O)=O)=C4C)C(C(C)O)=C3C
化学属性
| Mol. Formula | C34H38N4O6.2ClH |
|---|---|
| Mol. Weight | 671.68 |
| TSCA | Yes |
别名和识别编码
| Chemical Name | Hematoporphyrin Dihydrochloride |
|---|---|
| MDL Number | MFCD00013470 |
| Beilstein Registry Number | 78957 |
| EC Number | 241-699-4 |
| CAS Number | 17696-69-4 |
| Synonym | Acido 1,3,5,8-tetrametil-2,4-bis(idrossietil)porpfina-6,7-dipropionico Hematoporphyrin IX dihydrochloride; 7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid hydrochloride Haematoporphyrin dihydrochloride |
| Merck Number | 14,4636 |
| Chemical Name Translation | 血卟啉二盐酸盐 |
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相关文献及参考
- [2]. Yuan SX, et, al. Underlying mechanism of the photodynamic activity of hematoporphyrin‑induced apoptosis in U87 glioma cells. Int J Mol Med. 2018 Apr;41(4):2288-2296.
- [3]. Tomio L, et, al. Effect of hematoporphyrin and red light on AH-130 solid tumors in rats. Acta Radiol Oncol. 1983;22(1):49-53.
- [1]. Olsen, K.W., Affinity chromatography of heme-binding proteins: synthesis and characterization of hematin- and hematoporphyrin-agarose. Methods Enzymol, 1986. 123: p. 324-31.
- [1]. Olsen, K.W., Affinity chromatography of heme-binding proteins: synthesis and characterization of hematin- and hematoporphyrin-agarose. Methods Enzymol, 1986. 123: p. 324-31.
- [2]. Yuan SX, et, al. Underlying mechanism of the photodynamic activity of hematoporphyrin‑induced apoptosis in U87 glioma cells. Int J Mol Med. 2018 Apr;41(4):2288-2296.
- [3]. Tomio L, et, al. Effect of hematoporphyrin and red light on AH-130 solid tumors in rats. Acta Radiol Oncol. 1983;
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 169 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - body temperature decrease REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 117,145,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 117,145,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 278 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - body temperature decrease REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 117,145,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(iss
