1-(Tert-Butyl)-3-(p-Tolyl)-1H-Pyrazolo[3,4-d]Pyrimidin-4-Amine 1-(叔丁基)-3-(对甲苯基)-1H-吡唑并[3,4-d]嘧啶-4-胺
CAS 172889-26-8 MFCD01076570
化学结构图
SMILES: Cc1ccc(-c2nn(C(C)(C)C)c3ncnc(N)c23)cc1
化学属性
| Mol. Formula | C16H19N5 |
|---|---|
| Mol. Weight | 281.36 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO |
别名和识别编码
| Chemical Name | 1-(Tert-Butyl)-3-(p-Tolyl)-1H-Pyrazolo[3,4-d]Pyrimidin-4-Amine |
|---|---|
| CAS Number | 172889-26-8 |
| Synonym | 1-(1,1-Dimethylethyl)-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 4-Amino-5-(methylphenyl)-7-(t-butyl)pyrazolo-(3,4-d)pyrimidine AGL 1872 PP1 PP1; PP 1; PP1. |
| MDL Number | MFCD01076570 |
| PubChem Substance ID | 329819992 |
| Formula | C16H19N5 |
| IUPAC Name | 1-(tert-butyl)-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| InChIKey | ZVPDNRVYHLRXLX-UHFFFAOYSA-N |
| InChI | InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19) |
| Canonical SMILES | NC1=C2C(N(C(C)(C)C)N=C2C3=CC=C(C)C=C3)=NC=N1 |
| Chemical Name Translation | 1-(叔丁基)-3-(对甲苯基)-1H-吡唑并[3,4-d]嘧啶-4-胺 |
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分类
- Nucleotides
- {SNA} Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Non-Receptor Tyrosine Kinase Biology, Non-Receptor Tyrosine Kinase Inhibitors, Pfizer Compounds, v-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Src)
- Heterocycles
- Bases & Related Reagent
- Protein Kinase Inhibitors and Activators
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index,
产品应用
- PP1 is a potent and selective Src family protein tyrosine kinase inhibitor. PP1 effectively blocks TGF-beta1-induced cell migration and invasion in both established and primary carcinoma cells. PP1 blocks TGF-beta1-mediated cellular responses by direct and differential inhibition of type I and type II TGF-beta receptors. PP1 was also found to potentiate tumor-suppressive effect of connexin 32 gene in renal cancer cells.
相关文献及参考
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安全信息
GHS Symbol
- P301+P310
- H301 Toxic if swallowed 吞食有毒
- R22 Harmful if swallowed 吞咽有害
