Dehydro Olmesartan 1-((2'-(1H-四唑-5-基)-[1,1'-联苯]-4-基)甲基)-4-(丙-1-烯-2-基)-2-丙基-1H-咪唑-5-羧酸
CAS 172875-98-8 MFCD72875988
化学结构图
SMILES: CC(=C)C1N=C(CCC)N(CC2C=CC(=CC=2)C2C=CC=CC=2C2=NNN=N2)C=1C(O)=O
化学属性
| Mol. Weight | 428.49 |
|---|---|
| Mol. Formula | C24H24N6O2 |
别名和识别编码
| CAS Number | 172875-98-8 |
|---|---|
| Chemical Name | Dehydro Olmesartan |
| Synonym | 4-(1-Methylethenyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid |
| Chemical Name Translation | 1-((2'-(1H-四唑-5-基)-[1,1'-联苯]-4-基)甲基)-4-(丙-1-烯-2-基)-2-丙基-1H-咪唑-5-羧酸 |
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分类
- Aromatics
- Heterocycles
- Nucleotides
- Bases & Related Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Olmesartan acid (O550001) derivative. A nonpeptide angiotensin II receptor antagonist.
相关文献及参考
- [2]. Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67(6):503-9.
- Yanagisawa, H., et al.: J. Med. Chem., 39, 323 (1996),
- [1]. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131(3):190-7.
- [1]. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131(3):190-7.
- [2]. Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67(6):503-9.
