CCT018159
CAS 171009-07-7 MFCD00710300
化学结构图
SMILES: CCc1cc(-c2n[nH]c(C)c2-c2ccc3c(c2)OCCO3)c(O)cc1O
化学属性
| Mol. Formula | C20H20N2O4 |
|---|---|
| Mol. Weight | 352.38 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | CCT018159 |
|---|---|
| Formula | C20H20N2O4 |
| Synonym | CCT018159; CCT-018159; CCT 018159. |
| IUPAC Name | 4-(4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylbenzene-1,3-diol |
| InChIKey | OWPMENVYXDJDOW-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H20N2O4/c1-3-12-8-14(16(24)10-15(12)23)20-19(11(2)21-22-20)13-4-5-17-18(9-13)26-7-6-25-17/h4-5,8-10,23-24H,3,6-7H2,1-2H3,(H,21,22) |
| Canonical SMILES | OC1=C(CC)C=C(C2=NNC(C)=C2C3=CC=C4OCCOC4=C3)C(O)=C1 |
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产品应用
- CCT018159 is a novel inhibitor of heat shock protein (Hsp) 90 with potential anticancer activity. CCT018159 inhibited human HSP90beta with comparable potency to 17-AAG and with similar ATP-competitive kinetics. The mean cellular GI(50) value of CCT018159 across a panel of human cancer cell lines, including melanoma, was 5.3 mumol/L. CCT018159 caused cell cytostasis associated with a G(1) arrest and induced apoptosis. CCT018159 also inhibited key endothelial and tumor cell functions implicated in invasion and angiogenesis.
