FTI-277 trifluoroacetate salt
CAS 170006-73-2 MFCD06795840
化学结构图
SMILES:
化学属性
| Mol. Formula | C22H29N3O3S2· xC2HF3O2 |
|---|---|
| Mol. Weight | 447.61 (free base basis) |
别名和识别编码
| Chemical Name | FTI-277 trifluoroacetate salt |
|---|---|
| Synonym | FTI-277 trifluoroacetate salt N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester trifluoroacetate salt |
| MDL Number | MFCD06795840 |
| PubChem Substance ID | 329799790 |
| CAS Number | 170006-73-2 (free base) |
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资金保障
专业采购外包团队在线服务
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分类
- {SNA} Bioactive Small Molecule Alphabetical Index,
- {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, F, Farnesyl transferase, G Protein Function, G Proteins and Cyclic Nucleotides, Post-translational Modification
- {SNA} Bioactive Small Molecule Alphabetical Index, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, F, Farnesyl transferase, G Protein Function, G Proteins and Cyclic Nucleotides, Post-translational Modification, 生化试剂, 生物
相关文献及参考
- [2]. Nakazawa H, et al. Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS One. 2015 Jan 16;10(1):e0116633.
- [3]. Virtanen SS, et al. Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells. Cell Biol Int. 2010 Aug;34(8):815-26.
- [1]. Cohen-Jonathan E, et al. The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS. Radiat Res. 1999 Oct;152(4):404-11.
- [1]. Cohen-Jonathan E, et al. The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS. Radiat Res. 1999 Oct;152(4):404-11.
- [2]. Nakazawa H, et al. Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS One. 2015 Jan 16;10(1):e0116633.
- [3]. Virtanen SS, et al
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
