Dibutyryl-Camp Sodium Salt 二丁酰基cAMP钠盐
CAS 16980-89-5 MFCD00005843
化学结构图
SMILES: [Na+].CCCC(=O)NC1N=CN=C2C=1N=CN2[C@@H]1O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]1OC(=O)CCC |&1:16,18,25,26|
化学属性
| Mol. Formula | C18H23N5NaO8P |
|---|---|
| Mol. Weight | 491 |
别名和识别编码
| Chemical Name | Dibutyryl-Camp Sodium Salt |
|---|---|
| Synonym | Bucladesine sodium salt, Dibutyryl cAMP sodium salt, Dibutyryl cyclic-AMP sodium salt |
| MDL Number | MFCD00005843 |
| PubChem Substance ID | 354335826 |
| EC Number | 241-059-4 |
| Chemical Name Translation | 二丁酰基cAMP钠盐 |
| CAS Number | 16980-89-5 |
| Merck Number | 1463 |
| LabNetwork Molecule ID | LN01321520 |
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分类
- {SNA} Core Bioreagents, Cyclic Nucleotide Metabolism, Cyclic Nucleotides and Analogs, G Proteins and Cyclic Nucleotides, Nucleosides and Nucleotides, Nucleotide Analogs, Research Essentials, 核苷，核苷酸和寡核苷酸, 生化试剂, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Bioactive Small Molecules, Cell Biology,
- {SNA} Bioactive Small Molecule Alphabetical Index, Cyclic Nucleotide Metabolism, Cyclic Nucleotides and Analogs, D-DIF, G Proteins and Cyclic Nucleotides, Kinase/Phosphatase Biology, Protein Kinase A (PKA), Serine/Threonine Kinase Activators, Serine/Threonine Kinase Biology, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- [2]. Mafune, E., M. Takahashi, and N. Takasugi, Effect of vehicles on percutaneous absorption of bucladesine (dibutyryl cyclic AMP) in normal and damaged rat skin. Biol Pharm Bull, 1995. 18(11): p. 1539-43.
- [3]. Rundfeldt, C., et al., The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation. Arch Dermatol Res, 2012.
- [4]. Salehi F, et al. Effect of bucladesine, pentoxifylline, and H-89 as cyclic adenosine monophosphate analog, phosphodiesterase, and protein kinase A inhibitor on acute pain. Fundam Clin Pharmacol. 2017 Aug;31(4):411-419.
- [5]. Shimojo M, et al. The cholinergic gene locus is coordinately regulated by protein kinase A II in PC12 cells. J Neurochem. 1998 Sep;71(3):1118-26.
- [1]. Sharifzadeh, M., et al., Post-training intrahippocampal infusion of nicotine-bucladesine combination causes a synergistic enhancement effect on spatial memory
安全信息
GHS Symbol
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
