(4S,7S,10S,13S)-7-(2-Carboxyethyl)-4-(Carboxymethyl)-10-Isopropyl-13-((4-Methyl-2-Oxo-2H-Chromen-7-Yl)Carbamoyl)-2,5,8,11-Tetraoxo-3,6,9,12-Tetraazapentadecan-15-Oic Acid (4S,7S,10S,13S)-7-(2-羧乙基)-4-(羧甲基)-10-异丙基-13-((4-甲基-2-氧代-2H-苯并吡喃-7-基)氨基甲酰基)-2,5,8,11-四氧代-3,6,9,12-四氮杂十五烷-15-酸
CAS 169332-61-0 MFCD00671411
化学结构图
SMILES: CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)NC1=CC=C2C(=C1)OC(=O)C=C2C
化学属性
| Mol. Formula | C30H37N5O13 |
|---|---|
| Mol. Weight | 675.64 |
别名和识别编码
| Chemical Name | (4S,7S,10S,13S)-7-(2-Carboxyethyl)-4-(Carboxymethyl)-10-Isopropyl-13-((4-Methyl-2-Oxo-2H-Chromen-7-Yl)Carbamoyl)-2,5,8,11-Tetraoxo-3,6,9,12-Tetraazapentadecan-15-Oic Acid |
|---|---|
| Synonym | Ac-DEVD-AMC |
| MDL Number | MFCD00671411 |
| PubChem Substance ID | 24890505 |
| CAS Number | 169332-61-0 |
| Chemical Name Translation | (4S,7S,10S,13S)-7-(2-羧乙基)-4-(羧甲基)-10-异丙基-13-((4-甲基-2-氧代-2H-苯并吡喃-7-基)氨基甲酰基)-2,5,8,11-四氧代-3,6,9,12-四氮杂十五烷-15-酸 |
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分类
- {SNA} A-AM, Apoptosis Enzymes, Apoptosis Reagents, Apoptosis and Cell Cycle, Application Index, Bioactive Small Molecule Alphabetical Index, Caspase 3, Caspase 3 Substrates, Caspase 7, Caspase 7 Substrates, Caspase Inhibitors and Substrates, Caspase Substrates, Caspases, Caspases Substrates, Cell Signaling Enzymes, Enzyme Substrates, Fluorimetric, Other Apoptosis Related Reagents, Peptides and Proteins, Peptides for Cell Biology, Substrates by Enzyme, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学,
相关文献及参考
- Nicholson, D.W., Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376 , 37, (1995) 摘要
- Marks, N., Activation of caspase-3 and apoptosis in cerebellar granule cells. J. Neurosci. Res. 52 , 334, (1998)
- He, J., et al., Protease activation and cleavage of poly(ADP-ribose) polymerase: an integral part of apoptosis in response to photodynamic treatment. Cancer Res. 58 , 940-946, (1998)
- Armstrong, R.C., et al., Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis. J. Neurosci. 17 , 553-562, (1997) 摘要
