CAS 1649-18-9 MFCD00866692-1-(4-fluorophenyl)-4-(4-(pyridin-2-yl)piperazin-1-yl)butan-1-one 1-(4-氟苯基)-4-(4-(吡啶-2-基)哌嗪-1-基)丁-1-酮 TAO{mole}

1-(4-fluorophenyl)-4-(4-(pyridin-2-yl)piperazin-1-yl)butan-1-one 1-(4-氟苯基)-4-(4-(吡啶-2-基)哌嗪-1-基)丁-1-酮

CAS 1649-18-9 MFCD00866692

化学结构图

SMILES: O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1

化学属性

Mol. Formula	C19H22FN3O
Mol. Weight	327.44
Appearance	白色或类白色结晶粉末。熔点91-93℃。
Solubility	DMSO 65 mg/mL Water <1 mg/mL Ethanol 34 mg/mL
Melting Point	87-89°C

别名和识别编码

Chemical Name	1-(4-fluorophenyl)-4-(4-(pyridin-2-yl)piperazin-1-yl)butan-1-one
CAS Number	1649-18-9
Synonym	1-(4-FLUORO-PHENYL)-4-(4-PYRIDIN-2-YL-PIPERAZIN-1-YL)-BUTAN-1-ONE 1-(4-Fluorophenyl)-4-(4-(2-pyridinyl)-1-piperazinyl)-1-butanone, 4-Fluoro-4-[4-(2-pyridyl)-1-piperazinyl]butyrophenone 1-(4-Fluorophenyl)-4-(4-(2-pyridinyl)-1-piperazinyl)-1-butanone, 4′-Fluoro-4-[4-(2-pyridyl)-1-piperazinyl]butyrophenone 1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone 1-(4-氟苯基)-4-[4-(2-吡啶基)-1-哌嗪]-1-丁酮 1-Butanone, 1-(4-fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]- 4’-fluoro-4-(4-(2-pyridyl)-1-piperazinyl)butyrophenone AZAPERON Azaperone Azeperone Butyrophenone, 4'-fluoro-4-[4-(2-pyridyl)-1-piperazinyl]- Eucalmyl Fluoperidol Sedaperone vet Suicalm {} {} {Chemicalbo {} {} {haz 氟苯酮哌吡嗪
MDL Number	MFCD00866692
EC Number	216-715-8
Chemical Name Translation	1-(4-氟苯基)-4-(4-(吡啶-2-基)哌嗪-1-基)丁-1-酮
Wiswesser Line Notation	T6N DNTJ D3VR DF& A- BT6NJ
Beilstein Registry Number	0565491
LabNetwork Molecule ID	LN00852123

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产品应用

Sedative; tranquilizer.

安全信息

RTECSEU4550000

GHS Symbol

Precautionary statements

P301+P310

Hazard statements

H301 Toxic if swallowed 吞食有毒

WGK Germany3

Signal word Danger

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes 6.1 Xn

Risk Statements

R22 Harmful if swallowed 吞咽有害

Storage condition 0-6°C

UN Number UN2811 6.1/PG 3

Packing GroupIII

Safety Statements

S3/14 Keep in a cool place away from ... (incompatible materials to be indicated by the manufacturer) 保存在阴凉场所，远离（生产厂家指明的不兼容的物料）；

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >40 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - nausea or vomiting
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 24,1798,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 202 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 24,1798,1974

TYPE OF TES

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 385 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 24,1798,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 179 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Wash

其他信息

用途二:安定药。有机中间体。
MOL 文件:1649-18-9.mol
用途一:用作有机合成中间体
Sigma Aldrich:1649-18-9(sigmaaldrich)
阿扎哌隆
Azaperone 是一种吡啶哌嗪和丁酰苯类抗精神病药，具有镇静和止吐的效果，主要是在兽医上用作镇静剂