Amentoflavone 穗花杉双黄酮
CAS 1617-53-4 MFCD00017470
化学结构图
SMILES: O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12
化学属性
| Mol. Formula | C30 H18 O10 |
|---|---|
| Mol. Weight | 538.46 |
| Melting Point | >300°C |
| Boiling Point | |
| Flash Point | - |
| Density |
别名和识别编码
| Chemical Name | Amentoflavone, from Selaginellae herba, content ≥90%, NIFDC traceable |
|---|---|
| Synonym | 4',5,7-Trihydroxy-8-[2-hydroxy-5-(4-oxo-5,7-dihydroxy-4H-1-benzopyran-2-yl)phenyl]flavone 5,7,4',5'',7'',4'''-Hexahydroxy-3',8''-biflavone AMENTOFLAVONE AMENTOFLAVONE WITH HPLC AMENTOFLAVONE hplc Amentoflavone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} amentoflavone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} amentoflavone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} |
| MDL Number | MFCD00017470 |
| Beilstein Registry Number | 380244 |
| CAS Number | 1617-53-4 |
| PubChem Substance ID | 5281600 |
| Chemical Name Translation | 穗花杉双黄酮 |
| Reaxys-RN | 380244 |
| LabNetwork Molecule ID | LN01263901 |
| InChI | InChI=1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H |
| Canonical SMILES | - |
| EC Number |
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分类
- {SNA} A - D, Alphabetical,
- {SNA} A-AM, Bioactive Small Molecules, Ginkgo biloba, Hematology and Histology, Hypericum perforatum (St John's wort), Natural Dyes, Nutrition Research, Phytochemicals by Plant (Food/Spice/Herb), Stains and Dyes, 细胞生物学
- {SNA} Ginkgo biloba, Hypericum perforatum (St John's wort), Natural Dyes, Phytochemicals by Plant (Food/Spice/Herb), Stains and Dyes, 细胞生物学, 营养研究, 血液学和组织学
- {SNA} A - D, Alphabetical, Analytical Standards, Chromatography, Flavonoids, Garcinia, Ginkgo,
产品应用
- Biflavonoid with anti-inflammatory, anti-viral and cancer chemopreventive activity. It inhibits vascularization of tumors by blocking the activity of angiogenic VEGFs. Blocks the induction of COX-2 and up-regulates PPAR-γ. It is a negative modulator of the GABAA receptor at the benzodiazepine binding site.
相关文献及参考
- [2]. Xu P, et al. Amentoflavone acts as a radioprotector for irradiated v79 cells by regulating reactive oxygen species (ROS), cell cycle and mitochondrial mass. Asian Pac J Cancer Prev. 2014;15(18):7521-6.
- [3]. Yang Y, et al. [Amentoflavone induces apoptosis in SW480 human colorectal cancer cells via regulating β-catenin and caspase-3 expressions]. Nan Fang Yi Ke Da Xue Xue Bao. 2014 Jun;34(7):1035-8.
- 1. Tarallo, V., et al., The biflavonoid amentoflavone inhibits neovascularization preventing the activity of proangiogenic vascular endothelial growth factors J. Biol. Chem. 286 , 19641-19651, (2011) 摘要
- Banerjee, T., et al., Inhibition of TNFα-induced cyclooxygenase-2 expression by amentoflavone through suppression of NF-κB activation in A549 cells. Mol. Cell Biochem. 238 , 105-110, (2002) 摘要
- Baureithel, K.H., et al., Inhibition of benzodiazepine binding in vitro by amentoflavone, a constituent of various species of Hypericum . Ph
安全信息
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
GHS Symbol
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
其他信息
- Sigma Aldrich:1617-53-4(sigmaaldrich)
- MOL 文件:1617-53-4.mol
- F:10
