Nelfinavir Mesylate 甲磺酸奈非那韦
CAS 159989-65-8 MFCD00931436
化学结构图
SMILES: CC1C(=CC=CC=1O)C(=O)N[C@@H](CSC1=CC=CC=C1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C.CS(O)(=O)=O
化学属性
| Mol. Formula | C32H45N3O4S · CH3SO3H · xH2O |
|---|---|
| Mol. Weight | 663.89 (anhydrous basis) |
别名和识别编码
| Chemical Name | Nelfinavir Mesylate |
|---|---|
| Synonym | Nelfinavir mesylate hydrate 3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate AG-1343 Nelfinavir methanesulfonate hydrate |
| MDL Number | MFCD00931436 |
| Chemical Name Translation | 甲磺酸奈非那韦 |
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分类
- {SNA} AIDS and Viral Research Reagents, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Immune Cell Signaling and Blood, Immune System Regulation, N, Pfizer Compounds, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} AIDS and Viral Research Reagents, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling and Blood, Immune System Regulation, N, Pfizer Compounds
相关文献及参考
- [2]. Gills JJ, et al. Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that inducesendoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo. Clin Cancer Res. 2007 Sep 1;13(17):5183-94.
- [3]. Kaldor SW, et al. Nelfinavir mesylate (AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease. J Med Chem. 1997 Nov 21;40(24):3979-85.
- [4]. Bono C, et al. The human immunodeficiency virus-1 protease inhibitor nelfinavir impairs proteasome activity and inhibits the proliferation of multiple myeloma cells in vitro and in vivo. Haematologica. 2012;97(7):1101‐1109.
- [5]. Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.
- [1]. Mondal D, et al. Nelfinavir suppresses signaling and nitric oxide production by human aortic endothelial cells: protective effe
安全信息
- H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
