Alvimopan 爱维莫潘
CAS 156053-89-3 MFCD56053893
化学结构图
SMILES: C[C@H]1CN(C[C@H](CC2C=CC=CC=2)C(=O)NCC(O)=O)CC[C@@]1(C)C1C=C(O)C=CC=1
化学属性
| Mol. Weight | 425 |
|---|---|
| Mol. Formula | C25H32N2O4 |
别名和识别编码
| CAS Number | 156053-89-3 |
|---|---|
| Chemical Name | Alvimopan |
| Synonym | N-[(2S)-2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]glycine ADL 8-2698 LY 246736 Entereg |
| Chemical Name Translation | 爱维莫潘 |
| MDL Number |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- Aromatics
- Chiral Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- A peripheral ?-opioid receptor antagonist. Gastroprokinetic.
相关文献及参考
- [2]. Erowele GI, et, al. Alvimopan (Entereg), a Peripherally Acting mu-Opioid Receptor Antagonist For Postoperative Ileus. P T. 2008 Oct;33(10):574-83.
- [3]. Meerveld BG, et, al. Preclinical studies of opioids and opioid antagonists on gastrointestinal function. Neurogastroenterol Motil. 2004 Oct;16 Suppl 2:46-53.
- Liu, S.S., et al.: Clin. Pharmacol. Ther., 68, 66 (2000),
- Taguchi, A., et al.: N. Engl. J. Med., 345, 935 (2001),
- Zimmerman, D.M., et al.: J. Med. Chem., 37, 2262 (1994),
- [1]. Bourdonnec BL, et, al. Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2006-12.
- [1]. Bourdonnec BL, et, al. Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2006-12.
- [2]. Erowele
