Ritonavir 利托那韦
CAS 155213-67-5 MFCD00927142
化学结构图
SMILES: CN(CC1=CSC(=N1)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)OCC1=CN=CS1)CC1=CC=CC=C1
化学属性
| Mol. Formula | C37H48N6O5S2 |
|---|---|
| Mol. Weight | 720.94 |
| Melting Point | 120-122 |
别名和识别编码
| Chemical Name | Ritonavir |
|---|---|
| CAS Number | 155213-67-5 |
| Synonym | A 84538 1,3-Thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate Ritonavir A-84538 No Abbott 84538 |
| MDL Number | MFCD00927142 |
| Chemical Name Translation | 利托那韦 |
| PubChem Substance ID | 329825441 |
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分类
- Pharmaceuticals
- {SNA} Bioactive Small Molecule Alphabetical Index, R, 生物活性小分子, 细胞生物学
- Anti-virals
- Non-nucleoside Reverse Transcriptase
- Intermediates & Fine Chemicals
- {SNA} Analytical Standards, EP Standards, EP Standards P - R, Pharmacopeia & Metrological Institutes Standards, 分析/色谱
- Inhibitors,
- {SNA} Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling,
产品应用
- A selective HIV protease inhibitor.
相关文献及参考
- [2]. Kumar GN, et al. Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes. J Pharmacol Exp Ther. 1996 Apr;277(1):423-31.
- [3]. Weichold FF, et al. HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells. J Hum Virol. 1999 Sep-Oct;2(5):261-9.
- [4]. Drewe J, et al. HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833. Biochem Pharmacol. 1999 May 15;57(10):1147-52.
- [5]. Kumar GN, et al. Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos. 1999 Aug;27(8):902-8.
- [6]. Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May
安全信息
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
GHS Symbol
- H302+H312+H332
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
