Pancuronium Dibromide 4-羟基-3-硝基苯胂酸
CAS 15500-66-0 MFCD00079223
化学结构图
SMILES: [Br-].[Br-].C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](OC(C)=O)[C@H](C[C@@]43C)[N+]3(C)CCCCC3)[C@@H]1C[C@@H]([C@@H]2OC(C)=O)[N+]1(C)CCCCC1
化学属性
| Mol. Formula | C35H60Br2N2O4 |
|---|---|
| Mol. Weight | 733 |
别名和识别编码
| Chemical Name | Pancuronium Dibromide |
|---|---|
| CAS Number | 15500-66-0 |
| Synonym | ######## 1,1′-[(2β,3α,5α,16β,17β)-3,17-bis(Acetyloxy)androstane-2,16-diyl]bis(1-methylpiperidinium) dibromide 1,1'-[(2b,3a,5a,16b,17b)-3,17-Bis(acetyloxy)androstane-2,16-diyl]bis(1-methylpiperidinium) dibromide 1,1'-[(2β,3α,5α,16β,17β)-3,17-bis(Acetyloxy)androstane-2,16-diyl]bis(1-methylpiperidinium) dibromide 1,1'-[(2β,3α,5α,16β,17β)-3,17-bis(Acetyloxy)androstane-2,16-diyl]bis(1-methylpiperidinium) dibromide Pancuronium bromide 5alpha-Androstan-3alpha,17beta-diol, 2beta,16beta-dipipecolinio-, Pancuronium bromide |
| MDL Number | MFCD00079223 |
| PubChem Substance ID | 24278623 |
| Beilstein Registry Number | 4226892 |
| EC Number | 239-532-5 |
| Chemical Name Translation | 4-羟基-3-硝基苯胂酸 |
| Wiswesser Line Notation | L E5 B666TJ A1 E1 FOV1 OOV1 G- AT6KTJ A1& P- AT6KTJA1 &E 2 |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Antagonists,
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cholinergics, Ion Channels, Ligand-Gated Ion Channels, Neuroscience, Neurotransmission, Neurotransmitters, Nicotinic Acetylcholine Receptor Modulators,
- Steroids
- Pharmaceuticals
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cholinergics, Ion Channels, Ligand-Gated Ion Channels, Neuroscience,
- Intermediates & Fine Chemicals
- {SNA} Analytical Standards, EP Standards, EP Standards P - R, Pharmacopeia & Metrological Institutes Standards, 分析/色谱
- {SNA}
产品应用
- A potent steroidal neuromuscular blocking agent; muscle relaxant.
相关文献及参考
- Buckett, W.R. et al.: Br. J. Pharmacol. Chemother., 32, 671 (1968); Mol, W.E.M. et al.: Biochem. Pharmacol., 44, 1453 (1992); Playfor, S.D. et al.: Paediatric Clin. Pharmacol., 553 (2006);
安全信息
GHS Symbol
- P301+P310
- H301 Toxic if swallowed 吞食有毒
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 167 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,353,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 21200 ug/kg TOXI
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Bird - chicken DOSE/DURATION : 63 ug/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Lungs, Thorax, or Respiration - other changes REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,715,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 202 mg/kg TOXIC EFFECTS : Behavioral - general anesthetic Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression REFERENCE : SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku, Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 22,187,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rode
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE : 36 ug/kg SEX/DURATION : female 8-16 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku, Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 22,187,1970
