2-(Morpholin-4-Yl)-Benzo[H]Chrome-4-One 2-(吗啉-4-基)-苯并[h]铬-4-酮
CAS 154447-35-5 MFCD06798345
化学结构图
SMILES: O=c1cc(N2CCOCC2)oc2c1ccc1ccccc12
化学属性
| Mol. Formula | C17H15NO3 |
|---|---|
| Mol. Weight | 281.3059 |
| Appearance | yellow solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 2-(Morpholin-4-Yl)-Benzo[H]Chrome-4-One |
|---|---|
| Synonym | 2-(Morpholin-4-yl)-benzo[h]chromen-4-one NU7026 NU7026; NU-7026; NU 7026. |
| MDL Number | MFCD06798345 |
| CAS Number | 154447-35-5 |
| Chemical Name Translation | 2-(吗啉-4-基)-苯并[h]铬-4-酮 |
| PubChem Substance ID | 329818582 |
| Formula | C17H15NO3 |
| IUPAC Name | 2-morpholino-4H-benzo[h]chromen-4-one |
| InChIKey | KKTZALUTXUZPSN-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2 |
| Canonical SMILES | O=C1C=C(N2CCOCC2)OC3=C1C=CC4=CC=CC=C43 |
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分类
- {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, DNA-dependent protein kinase (DNA-PK), Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Kinase/Phosphatase Biology, N, P to Q, Protein kinase, DNA dependent, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
- {SNA} Bioactive Small Molecule Alphabetical Index, DNA-dependent protein kinase (DNA-PK), Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Kinase/Phosphatase Biology, N, P to Q, Protein kinase, DNA dependent, Serine/Threonine Kinase Biology,
产品应用
- NU-7026 is a potent DNA-PK inhibitor with potential anticancer activity.
相关文献及参考
- Hollick, J. J. et al., 2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK). Bioorg. Med. Chem. Lett. 13 , 3083-3086 , (2003)
