(3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-(Pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-Dodecahydro-1H-Cyclopenta[a]Phenanthren-3-ol (3S,8R,9S,10R,13S,14S)-10,13-二甲基-17-(吡啶-3-基)-2,3,4,7,8,9,10,11,12,13,14,15-十二烷基-1H-环戊[a]菲蒽-3-醇
CAS 154229-19-3 MFCD00924100
化学结构图
SMILES: C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CC=C2C1C=NC=CC=1
化学属性
| Mol. Formula | C24H31NO |
|---|---|
| Mol. Weight | 350 |
| Melting Point | 226.0 to 230.0 deg-C |
别名和识别编码
| Chemical Name | (3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-(Pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-Dodecahydro-1H-Cyclopenta[a]Phenanthren-3-ol |
|---|---|
| CAS Number | 154229-19-3 |
| Synonym | (3?)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol CB 7598 |
| Chemical Name Translation | (3S,8R,9S,10R,13S,14S)-10,13-二甲基-17-(吡啶-3-基)-2,3,4,7,8,9,10,11,12,13,14,15-十二烷基-1H-环戊[a]菲蒽-3-醇 |
| MDL Number | MFCD00924100 |
| Reaxys-RN | 7309269 |
| PubChem Substance ID | 253661112 |
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分类
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Steroids,
产品应用
- Abiraterone, a steroidal cytochrome P 450 17?-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent pr
相关文献及参考
- [2]. Richards J, et al. Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100. Cancer Res. 2012 May 1;72(9):2176-82.
- [3]. Stein MN, et al. Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer. Asian J Androl. 2014 May-Jun;16(3):387-400.
- [4]. Li R, et al. Abiraterone inhibits 3β-hydroxysteroid dehydrogenase: a rationale for increasing drug exposure in castration-resistant prostate cancer. Clin Cancer Res. 2012 Jul 1;18(13):3571-9.
- [5]. Kumar SV, et al. Validated RP-HPLC/UV method for the quantitation of abiraterone in rat plasma and its application to a pharmacokinetic study in rats. Biomed Chromatogr. 2013 Feb;27(2):203-7.
- [6]. Stein MN, et al. Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer. Asian J Androl. 2014 May-Jun;16(3):387-400.
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安全信息
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
GHS Symbol
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P405 Store locked up. 上锁保管。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P308+P313
