N-(2-((6-(2,6-Dichloro-3,5-Dimethoxyphenyl)Quinazolin-2-Yl)Amino)-3-Methylphenyl)Acrylamide N-[2-[[6-(2,6-二氯-3,5-二甲氧基苯基)-2-喹唑啉基]氨基]-3-甲基苯基]-2-丙烯酰胺
CAS 1538604-68-0 MFCD638604680
化学结构图
SMILES: C=CC(=O)Nc1cccc(C)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)ccc2n1
化学属性
| Mol. Weight | 509.38 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | N-[2-[[6-(2,6-二氯-3,5-二甲氧基苯基)-2-喹唑啉基]氨基]-3-甲基苯基]-2-丙烯酰胺 |
|---|---|
| Chemical Name | N-(2-((6-(2,6-Dichloro-3,5-Dimethoxyphenyl)Quinazolin-2-Yl)Amino)-3-Methylphenyl)Acrylamide |
| Formula | C26H22Cl2N4O3 |
| Synonym | BLU9931; BLU-9931; BLU 9931. |
| IUPAC Name | N-(2-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide |
| InChIKey | TXEBNKKOLVBTFK-UHFFFAOYSA-N |
| InChI | InChI=1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10-17(16)31-26)22-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33)(H,29,31,32) |
| Canonical SMILES | C=CC(NC1=CC=CC(C)=C1NC2=NC=C3C=C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C=CC3=N2)=O |
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产品应用
- BLU9931 is a potent and irreversible small-molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 signaling pathway. BLU9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. BLU9931 shows remarkable antitumor activity in mice bearing an HCC tumor xenograft that overexpresses FGF19 due to amplification as well as a liver tumor xenograft that overexpresses FGF19 mRNA but lacks FGF19 amplification. Approximately one third of patients with HCC whose tumors express FGF19 together with FGFR4 and its coreceptor klotho β (KLB) could potentially respond to treatment with an FGFR4 inhibitor.
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