4-羧基-1,3-氧氮杂戊 4-羧基-1,3-氧氮杂戊
CAS 153259-65-5 MFCD53259655
化学结构图
SMILES: COc1ccc(C2(C#N)CCC(C(=O)O)CC2)cc1OC1CCCC1
化学属性
| Mol. Weight | 343.42 |
|---|---|
| Mol. Formula | C20H25NO4 |
别名和识别编码
| CAS Number | 153259-65-5 |
|---|---|
| Chemical Name | 4-羧基-1,3-氧氮杂戊 |
| Synonym | Ariflo Cilomilast SB 207499 cis-4-Cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexanecarboxylic Acid |
| Chemical Name Translation | 4-羧基-1,3-氧氮杂戊 |
| PubChem Substance ID | 151170 |
| InChI | InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23) |
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分类
- Aromatics
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Selective phosphodiesterase 4 (PDE4) inhibitor. Antiasthmatic; used in treatment of chronic obstructive pulmonary disease.
相关文献及参考
- [2]. Hatzelmann A, et, al. Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro. J Pharmacol Exp Ther. 2001 Apr;297(1):267-79.
- [3]. Barnette MS, et, al. SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions. J Pharmacol Exp Ther. 1998 Jan;284(1):420-6.
- Barnette, M.S., et al.: J. Pharmacol. Exp. Ther., 284, 420 (1998),
- Torphy, TJ., et al.: Pulm. Pharmacol. Ther., 12, 131 (1999),
- Zussman, B.D., et al.: Pharmacotherapy, 21, 653 (2001),
- [1]. Griswold DE, et, al. SB 207499 (Ariflo), a second generation phosphodiesterase 4 inhibitor, reduces tumor necrosis factor alpha and interleukin-4 production in vivo. J
- [1]. Griswold DE, et, al. SB 207499 (Ariflo), a second generation phosphodiesterase 4 inhibitor, reduces tumor necrosis factor alpha and interleukin-4 production in vivo. J Pharmacol Exp Ther. 1998 Nov;287(2):705-11.
