4-(4-(4-Fluorophenyl)-5-(Pyridin-4-yl)-1H-Imidazol-2-yl)Phenol 4-(4-(4-氟苯基)-5-(吡啶-4-基)-1H-咪唑-2-基)苯酚
CAS 152121-30-7 MFCD00941964
化学结构图
SMILES: OC1C=CC(=CC=1)C1NC(=C(N=1)C1C=CC(F)=CC=1)C1C=CN=CC=1
化学属性
| Mol. Formula | C20H14FN3O |
|---|---|
| Mol. Weight | 331.34 |
| Density | 1.31 |
| Boiling Point | 565.71 |
| Melting Point | 240-243 |
别名和识别编码
| Chemical Name | 4-(4-(4-Fluorophenyl)-5-(Pyridin-4-yl)-1H-Imidazol-2-yl)Phenol |
|---|---|
| Synonym | |
| MDL Number | MFCD00941964 |
| PubChem Substance ID | 24278272 |
| CAS Number | 152121-30-7 |
| Chemical Name Translation | 4-(4-(4-氟苯基)-5-(吡啶-4-基)-1H-咪唑-2-基)苯酚 |
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分类
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Diversification Ready Pharma-Developed Compounds, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Fluorination Ready Pharma-Developed Compounds, GlaxoSmithKline, Kinase/Phosphatase Biology, P to Q, Protein Kinase Inhibitors, Protein Kinase p38 MAPK, S, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, p38 Mitogen-Activated protein kinase (p38MAPK), 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
相关文献及参考
- Venugopal SK, Chen J, Zhang Y, Clemens D, Follenzi A, Zern MA, Role of MAPK phosphatase-1 in sustained activation of JNK during ethanol-induced apoptosis in hepatocyte-like VL-17A cells. J. Biol. Chem. , 31900-8, (2007) 摘要
- Steinberg R, et. al., A protein kinase Cepsilon-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2. J. Biol. Chem. , 32288-97, (2007) 摘要
- Das R, et. al., Structural inference of native and partially folded RNA by high-throughput contact mapping. Proc. Natl. Acad. Sci. U. S. A. , 4144-9, (2008) 摘要
- Song, J.Y., et al., Expression Of A Homeostatic Regulator, Wip1 (wild-type P53-induced Phosphatase), Is Temporally Induced By C-Jun And P53 In Response To UV Irradiation. J. Thorac. Cardiovasc. Surg. 285 , 9067-76, (2010)
- Warrior, U., et al., Development of p38 kinase binding assay for high throughput screening. J. Biomol. Screen. 4 , 129-135 , (1999)
- Fox, T., et al., A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase. Protein Sci. 7 , 2249-2255 , (1998) 摘要
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
