CAS 149-29-1 MFCD00005858-Patulin 展青霉素/棒曲霉素 TAO{mole}

Patulin 展青霉素/棒曲霉素

CAS 149-29-1 MFCD00005858

化学结构图

SMILES: O=C1C=C2C(=CCOC2O)O1

化学属性

Mol. Formula	C7
Mol. Weight	154
Density	1.52
Melting Point	112-114
Solubility	Soluble in water, 100% ethanol (25 mg/mL), ethyl acetate (50 mg/mL), amyl acetate, DMSO (10 mg/mL), acetone, ethyl ether (sparingly), benzene (sparingly), and dichloromethane (10 mg/mL)

别名和识别编码

Chemical Name	Patulin
CAS Number	149-29-1
Synonym	N-HEXADECANOYLTRYPTAMINE N-[2-(3-INDOLYL)ETHYL]HEXADECANAMIDE 棒曲霉素溶液 PAT 展青霉素/叫棒曲霉素/开放毒霉素 clavatin Mycoine C3 Clavacin 叫棒曲霉素 2,4-Dihydroxy-2H-pyran-delta-3(6H),alpha-acetic acid-3,4-lactone (2,4-Dihydroxy-2H-pyran-3(6H)-ylidene)acetic acid-3,4-lactone PATULIN, PENICILLIUM EXPANSUM Clairformin Clavatin PALMITIC ACID TRYPTAMIDE 2H-Pyran-delta(sup 3(6H),alpha)-acetic acid, 2,4-dihydroxy-, 3,4-lactone Expansin 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one 4-Hydroxy-4H-furo(3,2-C)pyran-2(6H)-one
MDL Number	MFCD00005858
Beilstein Registry Number	149675
EC Number	205-735-2
PubChem Substance ID	4696
Chemical Name Translation	展青霉素/棒曲霉素
Merck Number	13,7125
Wiswesser Line Notation	T56 BOV GO IU&TJ FQ
LabNetwork Molecule ID	LN01307311
InChI	InChI=1S/C7H6O4/c8-6-3-4-5(11-6)1-2-10-7(4)9/h1,3,7,9H,2H2

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

An inhibitor of protein prenylation

安全信息

RTECSLV2625000

GHS Symbol

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P305+P351+P338

Hazard statements

H332 Harmful if inhaled 吸入有害
H319 Causes serious eye irritation 严重刺激眼睛
H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H312 Harmful in contact with skin 皮肤接触有害
H302 Harmful if swallowed 吞食有害
H315 Causes skin irritation 会刺激皮肤
H300 Fatal if swallowed 吞食致命

WGK Germany3

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges Eyeshields, Gloves Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Signal word

Hazard Codes T F,Xn T,Xn

Safety Statements

S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R25 Toxic if swallowed 吞咽有毒
R22 Harmful if swallowed 吞咽有害
R38 Irritating to skin 刺激皮肤
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R48/20/22
R11 Highly flammable 非常易燃
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R36 Irritating to eyes 刺激眼睛

Packing GroupII

UN Number UN 3462 6.1/PG 2

Hazard Class6.1(a)

Storage condition -20°C 储存温度：-20°C 储存温度-20°C

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 232 mg/kg/58W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   15,85,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   2,109,1946

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - food intake (animal)
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 17,605,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percen

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Liver - fatty liver degeneration
   Kidney, Ureter, Bladder - other c

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 23 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 18,173,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Bird - chick

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 3200 ug/L
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   68,619,1977

TYPE OF TEST            : DNA damage
TEST SYSTEM

TYPE OF TEST            : Mutation test

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 100 ug/L
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   68,619,1977

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 2 mg/L
REFERENCE :
   FOBLAN Folia Biologica (Prague).  (Academic Press Inc. Ltd., 24-28 Oval Rd.,
   London NW1 7DX, UK) V.1-    1955-  Volume(issue)/page/year: 32,128,1986

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Fibroblast
DOSE/DURATION           : 2 mg/L
REFERENCE :
   FOBLAN Folia Biologica (Prague).  (Academic Press Inc. Ltd., 24-28 Oval Rd.,
   London NW1 7DX, UK) V.1-    1955-  Volume(issue)/page/year: 32,128,1986

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 mg/L
REFERENCE :
   AEMIDF Applied and Environmental Microbiology.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.31-    1976-
   Volume(issue)/page/year: 52,1046,1986

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE

TYPE OF TEST            : DNA dam

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 24 mg/kg
SEX/DURATION            : female 14-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 16,243,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 135 mg/kg
SEX/DURATION            : male 5 week(s) pre-mating
                          female 5 week(s) pre-mating  - 20 day(s) after
                          conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - urogenital system
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 2,713,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 675 mg/kg
SEX/DURATION            : male 5 week(s) pre-mating
                          female 5 week(s) pre-mating  - 20 day(s) after
                          conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, W

其他信息

毒性分级:剧毒
棒曲霉素是属于真菌毒素的一类有毒化合物，主要是青霉属、曲霉属、裸囊菌属等多种真菌的次生代谢产物 , 在果品、蔬菜、果蔬汁、果酒等食品中都发现了棒曲霉素。棒曲霉素为无色针状结晶，能溶于水、乙醇、丙酮、乙酸乙酯和氯仿，不溶于石油醚, 在碱性溶液中不稳定 , 易被破坏 , 而在酸性环境中稳定性增加。
类别:有毒物质
灭火剂:水, 二氧化碳, 干粉, 砂土
MOL 文件:149-29-1.mol
叫棒曲霉素价格(试剂级):更新日期产品编号产品名称包装价格 2010/06/21 228870250 叫棒曲霉素 Patulin 99% 25 MG 7175元 2010/06/21 228870100 叫棒曲霉素 Patulin 99% 10 MG 3055元 2010/06/21 228870050 叫棒曲霉素 Patulin 99% 5 MG 1744元
储运特性:库房低温, 通风, 干燥; 与食品原料分开存放
Patulin, a mycotoxin, has been reported to contain antibiotic characteristics. This compound displays the ability to specifically inhibit Na+-K+ ATPase. In murine studies, Patulin was found to inhibit protein prenylation in cells. Mechanistic studies suggest that Patulin reduces incorporation of mevalonate into proteins and prevents protein transferase action, which is required for protein prenylation. Additional experiments show that this mycotoxin also inhibits cell-free microtubule polymerization by covalently reacting with thiol groups of microtubule proteins.
可燃性危险特性:可燃, 火场排出辛辣刺激烟雾
Acros Organics:展青霉素/棒曲霉素 Patulin, 99%(149-29-1)
急性毒性:口服- 大鼠 LD50 27.79 毫克/ 公斤; 口服- 小鼠 LD50: 17 毫克/公斤
外观性质:棒曲霉素是属于真菌毒素的一类有毒化合物，主要是青霉属、曲霉属、裸囊菌属等多种真菌的次生代谢产物 , 在果品、蔬菜、果蔬汁、果酒等食品中都发现了棒曲霉素。棒曲霉素为无色针状结晶，能溶于水、乙醇、丙酮、乙酸乙酯和氯仿，不溶于石油醚, 在碱性溶液中不稳定 , 易被破坏 , 而在酸性环境中稳定性增加。熔点：108-111℃
Sigma Aldrich:149-29-1(sigmaaldrich)
用途一:毒枝菌素，带有抗细菌、抑制钾吸收和可能的致癌活性。