2-(7-Aza-1H-Benzotriazole-1-yl)-1,1,3,3-Tetramethyluronium Hexafluorophosphate O-(7-氮苯并三氮唑)-N,N,N,N-四甲基脲六氟磷酸酯

CAS 148893-10-1 MFCD00274639

化学结构图

148893-10-1
SMILES: CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F

化学属性

Mol. FormulaC10H15F6N6OP
Mol. Weight380.23
Melting Point183-188 °C
TSCANo
Density1.422
SolubilitySoluble in Acetone and DMSO
Stability对热敏感,易吸潮
pH:A

别名和识别编码

Chemical Name2-(7-Aza-1H-Benzotriazole-1-yl)-1,1,3,3-Tetramethyluronium Hexafluorophosphate
CAS Number148893-10-1
Alfabeta NameAZABENZOTRIAZOLYLTETRAMETHYLURONIUMHEXAFLUOROPHOSPHATE OHNNNN711()--------,,,''
MDL NumberMFCD00274639
Synonym HATU {LY} HATU {} {LY} HATU {} {} {LY} HATU {} {} {} {LY} HATU {} {} {} {} {LY} HATU {} {} {} {} {} {LY} HATU {} {} {} {} {} {} {LY} HATU {} {} {} {} {} {} {} {LY} HATU {} {} {} {} {} {} {} {} {LY} HATU {} {} {} {} {} {} {} {} {} {LY} HATU {} {} {} {} {} {} {} {} {} {} {LY} HATU {} {} {} {} {} {} {} {} {} {} {} {LY} HATU {} {} {} {} {} {} {} {} {} {} {} {} {LY} HATU {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} HATU {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} HATU {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} HATU {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} HATU {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} O-(7-Azabenzotriazol-1-yl)-N,N,N,N-tetramethyl uronium hexafluorophosphate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} O-(7-Azabenzotriazol-1-yl)-N,N,N,N-tetramethyl uronium he
PubChem Substance ID125307047
EC Number250-023-7
Beilstein Registry Number2384789
Chemical Name TranslationO-(7-氮苯并三氮唑)-N,N,N,N-四甲基脲六氟磷酸酯
Reaxys-RN11805773
LabNetwork Molecule IDLN00168368
Canonical SMILESF[P-](F)(F)(F)(F)F.C/[N+](C)=C(N(C)C)/ON1C2=NC=CC=C2N=N1
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分类

  • Miscellaneous Reagents
  • {SA} Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling, Phosphonium/Uronium/Formamidinium, Synthetic Reagents

产品应用

  • 用于固相多肽合成,最近的研究显示:这种偶联试剂的结晶或溶液结果是胍的N-氧化物形式(guanidinium N-oxide),而不是一种尿化合物。

相关文献及参考

  • Barber, C., et al.: Bioorg. Med. Chem. Lett., 19, 1499 (2009),
  • Merck: 14,10421
  • Chollet, C., et al.: Bioorg. Med. Chem., 17, 2512 (2009),
  • 2. Giorgio Cevasco, et al J. Chromatogr. A. 1218 , 787-792, (2011)

安全信息

Warnings IRRITANT
Hazard Codes Xi,Xn E,Xi Xi
WGK Germany3
GHS Symbol
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P332+P313
  • P305+P351+P338+P337+P313
  • P302+P350
  • P337+P313
  • P302+P352+P332+P313+P362+P364
Signal word Danger
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H228 Flammable solid 易燃固体
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S37 Wear suitable gloves 戴适当手套;
  • S35 This material and its container must be disposed of in a safe way 该物料及其容器必须以安全方式处置;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Risk Statements
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

其他信息

  • Sigma Aldrich:148893-10-1(sigmaaldrich)
  • 用途一:用于固相多肽合成,最近的研究显示:这种偶联试剂的结晶或溶液结果是胍的N-氧化物形式(guanidinium N-oxide),而不是一种尿化合物。
  • F:10-21
  • 外观性质:白色结晶粉末,熔点:183~186℃
  • MOL 文件:148893-10-1.mol
  • Alfa Aesar:O-(7-氮苯并三氮唑)-N,N,N',N'-四甲基脲六氟磷酸酯,99% O-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, 99%(148893-10-1)
  • HATU2-(7-偶氮苯并三氮唑)-N,N,N',N'-四甲基脲六氟磷酸酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw020053 2-(7-氮苯并三氮唑)-N,N,N’,N’-四甲基脲六氟磷酸酯(HATU) +4℃ 5g 180元 2010/05/25 H26082 O-(7-氮苯并三氮唑)-N,N,N',N'-四甲基脲六氟磷酸酯,99% O-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, 99% 5g 2674元 2010/05/25 H26082 O-(7-氮苯并三氮唑)-N,N,N',N'-四甲基脲六氟磷酸酯,99% O-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, 99% 25g 10514元

系列性分类


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