CAS 148-79-8 MFCD00005587-Thiabendazole 噻菌灵 TAO{mole}

Thiabendazole 噻菌灵

CAS 148-79-8 MFCD00005587

化学结构图

SMILES: c1ccc2[nH]c(-c3cscn3)nc2c1

化学属性

Mol. Formula	C10H7N3S
Mol. Weight	201.25
Melting Point	298-301 °C
Solubility	Soluble in ethanol (1 mg/ml), DMF (50 mg/ml), chlorinated hydrocarbons (slightly), DMSO (40 mg/ml), and water (<1 mg/ml).
Appearance	powder
Density	1.406
Boiling Point	446.0±37.0 °C at 760 mmHg

别名和识别编码

Chemical Name	Thiabendazole
CAS Number	148-79-8
Synonym	Thiabendazole {LY} Thiabendazole {} {LY} Thiabendazole {} {} {LY} Thiabendazole {} {} {} {LY} Thiabendazole {} {} {} {} {LY} Thiabendazole {} {} {} {} {} {LY} Thiabendazole {} {} {} {} {} {} {LY} Thiabendazole {} {} {} {} {} {} {} {LY} Thiabendazole {} {} {} {} {} {} {} {} {LY} Thiabendazole {} {} {} {} {} {} {} {} {} {LY} Thiabendazole {} {} {} {} {} {} {} {} {} {} {LY} Thiabendazole {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} Thiabendazole {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thiabendazole {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thiabendazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thiabendazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thiabendazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thiabendazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID	5430
EC Number	205-725-8
Beilstein Registry Number	611403
MDL Number	MFCD00005587
Reaxys-RN	783842
Merck Number	9289
Chemical Name Translation	噻菌灵
Wiswesser Line Notation	T56 BM DNJ C- ET5N CSJ
LabNetwork Molecule ID	LN00244108
InChI	InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)
Canonical SMILES	C1(C2=CSC=N2)=NC3=CC=CC=C3N1

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产品应用

内吸性杀菌剂。能防止多种植物的真菌病害，用于处理收获后的水果和蔬菜，可防止贮存中发生的上些病害，目前国内外已广泛应用。

安全信息

GHS Symbol

WGK Germany2

Hazard Codes 9 N

Hazard statements

H303 May be harmfully swallowed 吞食可能有害
H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。

Personal Protective Equipment Eyeshields, Gloves dust mask type N95 (US), Eyeshields, Gloves

RTECSDE0700000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P307+P311
P308+P311
P308+P313
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Warning

UN Number 3077 UN 3077 9/PG 3

Safety Statements

S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R50/53

Packing GroupIII

Hazard Class9

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 175 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Reproductive - Tumorigenic effects - testicular tumors
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   29,771,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - domestic
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VMDNAV Veterinarno-Meditsinski Nauki.  Veterinary Science.  (Hemus, Blvd.
   Russki 6, Sofia, Bulgaria) V.1-    1964-  Volume(issue)/page/year:
   19(3),99,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2080 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   SRTCAC Science Reports of the Research Institutes, Tohoku University, Series
   C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
   Cancer, 4-1 Seiryo-machi, Sendai, Japan)  V.1-   1949-
   Volume(issue)/page/year: 36(1-4),10,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 55(10),28,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   VMDNAV Veterinarno-Meditsinski Nauki.  Veterinary Science.  (Hemus, Blvd.
   Russki 6, Sofia, Bulgaria) V.1-    1964-  Volume(issue)/page/year:
   1

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 666 ug/plate
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11(Suppl 12),1,1988

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - rat Bone marrow
DOSE/DURATION           : 100 nmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 188,1,1987

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 80 umol/L
REFERENCE :
   BBACAQ Biochimica et Biophysica Acta.  (Elsevier Science Pub. B.V., POB 211,
   1000 AE Amsterdam, Netherlands)  V.1-    1947- Volume(issue)/page/year:
   543,82,1978

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 600 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 287,57,1993

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2368 mg/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho.  Annual Report of Tokyo
   Metropolitan Research Laboratory of Public Health.  (Tokyo-toritsu Eisei
   Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1-
      1949/50-  Volume(issue)/page/year: 37,421,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 11700 mg/kg
SEX/DURATION            : female 7-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho.  Annual Report of Tokyo
   Metropolitan Research Laboratory of Public Health.  (Tokyo-toritsu Eisei
   Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1-
      1949/50-  Volume(issue)/page/year: 29,112,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 240 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   22,509,1984

{h

其他信息

用途五:内吸性杀菌剂。能防治多种植物的真菌病害，用于处理收获后的水果和蔬菜，可防治贮存中发生的上些病害，目前国内外已广泛应用。例如，柑桔用500-1000ppm药液浸，防治贮存期青霉病、绿霉病；香蕉用750-1500ppm药液浸，防治贮存期冠腐病、炭疽病；还可用500-1000ppm药液浸苹果、梨、菠萝、葡萄、草莓、甘蓝、白菜、蕃茄、蘑菇、甜菜、甘庶等，防治贮存期病害。
储运特性:库房通风低温干燥; 与食品原料分开储运
概述:噻菌灵俗称特克多、涕必灵、硫苯唑、噻苯咪唑、噻苯哒唑，具内吸向顶传导性能，但不能向基传导。持效期长，与苯并咪唑类杀菌剂有交互抗性。对子囊菌、担子菌
{Chemic
color:light yellow
白色至灰白色无味粉末。不溶于水，微溶于醇、丙酮，易溶于乙醚、氯仿。在25℃，PH2.0的水中溶度为1%，在PH5
用途三:作保鲜剂，我国规定可用于水果保鲜，最大使用量为0.02g/kg。
概述:噻菌灵俗称特克多、涕必灵、硫苯唑、噻苯咪唑、噻苯哒唑，具内吸向顶传导性能，但不能向基传导。持效期长，与苯并咪唑类杀菌剂有交互抗性。对子囊菌、担子菌和半知菌有抑制活性，用于防治多种作物真菌病害及果蔬防腐保鲜。是一种高效、广谱、国际上通用的杀菌剂. 用于加工42%噻菌灵悬浮剂，60%噻菌灵可湿性粉剂、3%噻菌灵烟剂、水果保鲜纸等。防治农作物、经济作物由真菌引起的各种病害。工业防霉剂，可用于饲料防霉，涂料防霉，作为纺织品、纸张、皮革、电线电缆
噻菌灵对于蔬菜、水果类的防
毒性分级:中毒
用途六:内吸性杀菌剂。能防止多种植物的真菌病害，用于处理收获后的水果和蔬菜，可防止贮存中发生的上些病害，目前国内外已广泛应用。例如，柑桔用500-1000ppm药液浸，防治贮存期青霉病，绿霉病。香蕉用750-1500ppm药液浸，防治贮存期冠腐病，炭疽病，还可用500-1000ppm药液浸苹果。梨，菠萝、葡萄、草莓、甘蓝、白菜、番茄、蘑菇、甜菜、甘蔗等，防治贮存期丙害。
MOL 文件:148-7
参考质量标准:日本标准，1992 含量/% 98.0~101.0 干燥失重/% ≤0.5 灼烧残渣/% ≤0.2 重金属(以Pb计)/% ≤0.002 熔点/℃ 296~303(分解)
方法三:方法一在175℃下由4-乙氧基甲酰噻唑与邻苯二胺在缩合磷酸中反应2h。反应物倾入冰水中，用氢氧化钠中和至Ph值6，析出结晶，过滤后用丙酮重结晶、活性炭脱色。脱色液经浓缩、真空干燥得成品。方法二在240℃下由4-噻唑羧基酰氨(或酰溴)与邻苯二胺在缩合磷酸中反应3h，反应物倾人冰水中，过滤后滤液用30%的氢氧化钠溶
不溶于水，微溶于醇、丙酮，易溶于乙醚、氯仿。在25℃，PH2.0的水中溶度为1%，在PH5-12水中溶解度低于50ppm。丙酮中溶解度为28G/L，苯2.3g/l，氯仿0.8g/L。甲醇9.3g/L，二甲基亚砜80g/L，二甲基甲酰胺39.0g/L。在水、酸、碱性溶液中均稳定。无臭，无味。
方法二:制备方法一 4-乙氧甲酰噻唑的制备以酒石酸为原料，经裂解得丙酮酸，再通过酯化、溴化后，与硫代甲酰
概述:噻菌灵俗称特克多、涕必灵、硫苯唑、噻苯咪唑、噻苯哒唑，具内吸向顶传导性能，但不能向基传导。持效期长，与苯并咪唑类杀菌剂有交互抗性。对子囊菌、担子菌和半知菌有抑制活性，用于防治多种作物真菌病害及果蔬防腐保鲜。是一种高效、广谱、国际上通用的杀菌剂. 用于加工42%噻菌灵悬浮剂，60%噻菌灵可湿性粉剂、3%噻菌灵烟剂、水果保鲜纸等。防治农作物、经济作物由真菌引起的各种病害。工业防霉剂，可用于饲料防霉，涂料防霉，作为纺织品、纸张、皮革、电线电缆和日常商业制品的防霉、防腐。人、畜肠道的驱虫药剂。噻菌灵的用法与用量亩用有效成分15～30克对水
白色至灰白色无味粉末。不溶于水，微溶于醇、丙酮，易溶于乙醚、氯仿。在25℃，PH2.0的水中溶度为1%，在PH5-12水中溶解度低于50ppm。丙酮中溶解度为28G/L，苯2.3g/l，氯仿0.8g/L。甲醇9.3g/L，二甲基亚砜80g/L，二甲基甲酰胺39.0g/L。在水、酸、碱性溶液中均稳定。无臭，无味。熔点:304-305℃