CETRORELIX ACETATE
CAS 145672-81-7 MFCD08459466
化学结构图
SMILES:
化学属性
| Mol. Formula | C70H92ClN17O14· xC2H4O2 |
|---|---|
| Mol. Weight | 1431.04 (free base basis) |
别名和识别编码
| Chemical Name | Cetrorelix acetate |
|---|---|
| Synonym | NS-75A Cetrotide N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide acetic acid salt SB-75 Cetrotide N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide acetic acid salt NS-75A SB-75 |
| MDL Number | MFCD08459466 |
| CAS Number | 145672-81-7 |
| Chemical Name Translation |
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分类
- Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Luteinizing Hormone (LH), Merck, Pituitary Hormones
- {SNA} Bioactive Small Molecule Alphabetical Index, C-CH, Cytokines, Growth Factors and Hormones, Hormones, Luteinizing Hormone (LH), Pituitary Hormones, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- [2]. Gründker C et al. Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod Biol Endocrinol. 2003 Oct 7;1:65.
- 1. Roth, C.L., et al., Different effects of agonistic vs. antagonistic GnRH-analogues (triptorelin vs. cetrorelix) on bone modeling and remodeling in peripubertal female rats Exp. Clin. Endocrinol. Diabetes 113 , 451-456, (2005)
- Kanaho, Y., et al., Neurotrophic effect of gonadotropin-releasing hormone on neurite extension and neuronal migration of embryonic gonadotropin-releasing hormone neurons in chick olfactory nerve bundle culture J. Neurosci. Res. 87 , 2237 - 2244, (2009) 摘要
- Merck 14 ,2026
- Telegdy, G., et al., Effects of the LHRH antagonist Cetrorelix on the brain function in mice Neuropeptides 43 , 229 234, (2009)
- Ziegler, CG., et al., Expression of neuropeptide hormone receptors in human adrenal tumors and cell lines: antiproliferative effects of peptide analogues Proc. Natl. Acad. Sci. U. S. A. , (200
安全信息
GHS Symbol
- P308+P313
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
- S22 Do not breathe dust 不要吸入粉尘；
- R60 May impair fertility 可能降低生殖能力
- R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
