CAS 144-83-2 MFCD00038036-Sulfapyridine 磺胺吡啶 TAO{mole}

Sulfapyridine 磺胺吡啶

CAS 144-83-2 MFCD00038036

化学结构图

SMILES: Nc1ccc(S(=O)(=O)Nc2ccccn2)cc1

化学属性

Mol. Formula	C11H11N3O2S
Mol. Weight	249.29
Melting Point	191-193°C
Solubility	<0.1 G/100 ML AT 22 ºC
Appearance	黄棕至白色粉末。熔点191-193℃。微溶于水。
Density	1.432
Boiling Point	473.5°C at 760mmHg
Flash Point	240.2°C

别名和识别编码

Chemical Name	Sulfapyridine
CAS Number	144-83-2
Alfabeta Name	AMINOPYRIDINYLBENZENESULFONAMIDE N42-----
MDL Number	MFCD00038036
Synonym	Sulfapyridine {LY} Sulfapyridine {} {LY} Sulfapyridine {} {} {LY} Sulfapyridine {} {} {} {LY} Sulfapyridine {} {} {} {} {LY} Sulfapyridine {} {} {} {} {} {LY} Sulfapyridine {} {} {} {} {} {} {LY} Sulfapyridine {} {} {} {} {} {} {} {LY} Sulfapyridine {} {} {} {} {} {} {} {} {LY} Sulfapyridine {} {} {} {} {} {} {} {} {} {LY} Sulfapyridine {} {} {} {} {} {} {} {} {} {} {LY} Sulfapyridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} Sulfapyridine {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sulfapyridine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sulfapyridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sulfapyridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sulfapyridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sulfapyridine {} {} {} {} {} {
PubChem Substance ID	87575694
Beilstein Registry Number	222065
EC Number	205-642-7
Chemical Name Translation	磺胺吡啶
Reaxys-RN	222065
Merck Number	8938
Wiswesser Line Notation	T6NJ BMSWR DZ
LabNetwork Molecule ID	LN00142404
Canonical SMILES	O=S(C1=CC=C(N)C=C1)(NC2=NC=CC=C2)=O

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分类

{SNA} APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Additional Standards, Analytical Standards, Antibiotics Standards, Chemical Structure, Chromatography, Clinical Standards, Pharmaceutical Standards, Pharmaceuticals, Illicit Drugs & Alcohol, Sulfapyridine, Sulfonamides, 分析/色谱
Sulfur & Selenium Compounds
{SNA} Analytical Standards, Antibiotics Standards, Pharmaceuticals, Illicit Drugs & Alcohol, 分析/色谱
{SNA} Analytical Standards, Analytical/Chromatography, Antibiotics, Chemical Structure, Chromatography, Clinical Standards, Sulfonamides
{uni_hamburg} no charge; nitrogen heterocycle; carbocycle; aromatic; 6RingOnly; 6ring; 1fragm

产品应用

医药中间体。

安全信息

Warnings IRRITANT

WGK Germany2

RTECSDA9625000

Storage condition 2-8°C {LY} 2-8°C 2-8℃ 2-8℃储存 {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

Safety Statements

GHS Symbol

Precautionary statements

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 135 mg/kg/9W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 68,330,1948

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15800 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB.  Volume(issue)/page/year:
   11,217,1938

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 211,367,1950

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 16600 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB.  Volume(issue)/page/year:
   11,217,1938

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 20 gm/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgiu

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 1667 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 283,59,1992

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 200 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 222,27,1989

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 3 gm/kg/48H (Intermittent)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 283,59,1992

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 714 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 283,53,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 12600 mg/kg
SEX/DURATION            : male 35 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 37,539,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 13482 mg/kg
SEX/DURATION            : male 6 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 81,259,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 46200 mg/kg
SEX/DURATION            : male 60 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   ANDRDQ Andrologia.  (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000
   Berlin 30, Fed. Rep. Ger.) V.6-    1974-  Volume(issue)/page/year:
   23,269,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10080 mg/kg
SEX/DURATION            : male 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive

其他信息

上游原料:2-氨基吡啶
用途一:医药中间体。
TCI Shanghai:磺胺吡啶 Sulfapyridine,>;98.0%(T)(144-83-2)
MOL 文件:144-83-2.mol
Sigma Aldrich:144-83-2(sigmaaldrich)
下游产品:柳氮磺吡啶
图谱信息:磺胺吡啶(144-83-2)核磁图( 1 HNMR) 磺胺吡啶(144-83-2)红外图谱(IR1) 磺胺吡啶(144-83-2)质谱(MS) 磺胺吡啶(144-83-2)红外图谱(IR2) 磺胺吡啶(144-83-2)核磁图( 13 CNMR)
磺胺吡啶价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 S0071 磺胺吡啶 Sulfapyridine 500G 2170元 2014/06/02 S0071 磺胺吡啶 Sulfapyridine 25G 305元
MSDS 信息:4-((2-Pyridylamino)sulfonyl)aniline(144-83-2).msds
方法一:2-氨基吡啶经缩合、水解而得。
微溶于水。