Polymyxin B Sulfate Salt 多粘菌素B硫酸盐
CAS 1405-20-5 MFCD00131991
化学结构图
SMILES: CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(Cc2ccccc2)NC(=O)C(CCN)NC1=O)C(C)O.O=S(=O)(O)O
化学属性
| Mol. Weight | 1386 |
|---|---|
| Mol. Formula | C55H96N16O13 |
| TSCA | No |
| Stability | 对光敏感 |
别名和识别编码
| MDL Number | MFCD00131991 |
|---|---|
| CAS Number | 1405-20-5 |
| EC Number | 215-774-7 |
| Synonym | N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-6-methyl-octanamide sulfuric acid Aerosporin 多粘菌素B硫酸盐 硫酸多粘菌素B 多粘菌素B 溶液 单核细胞增多性李斯特菌选择性添加剂 I 多粘菌素 B 硫酸盐 单核细胞增生李斯特菌选择性添加剂 I 多粘菌素 B 硫酸盐 |
| Chemical Name | Polymyxin B Sulfate Salt |
| Merck Number | 7573 |
| Reaxys-RN | 9186516 |
| PubChem Substance ID | 125307819 |
| Chemical Name Translation | 多粘菌素B硫酸盐 |
| InChIKey | HNDFYNOVSOOGDU-UHFFFAOYSA-N |
| InChI | InChI=1S/C56H98N16O13.H2O4S/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79;1-5(2,3)4/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80);(H2,1,2,3,4) |
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分类
- {SNA} Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Chemical Structure Class, Interferes with Cell Membrane Permeability (Ionophores), L - Z, Mechanism of Action, Peptides, Spectrum of Activity
- {SA} Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Chemical Structure Class, Interferes with Cell Membrane Permeability (Ionophores), L - Z, Mechanism of Action, Peptides, Spectrum of Activity
- {SNA} Antibacterial,
产品应用
- 多粘菌素B为抗革兰阴性杆菌多肽类抗生素, 可以改变膜结构使小分子物质泄漏而抑制革兰氏阴性菌的生长。对大肠杆菌具有杀菌作用。结合到细菌脂多糖类的脂质A部分。在外皮细胞膜诱发小孔。
- 作用模式: 结合并干涉细胞质膜的渗透性。
- 抗菌谱: 革兰式阴性细菌。
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- R22 Harmful if swallowed 吞咽有害
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P301+P312+P330
- P501 Dispose of contents/container to..… 处理内容物/容器.....
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 59500 ug(base)/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 7,41,1959/1960
TYPE OF TES
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 8 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : INURAQ Investigative Urology. (Baltimore, MD) V.1-19, 1963-81. For publisher information, see JOURAA. Volume(issue)/page/year: 6,505,1969
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intracerebral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 320 ug/kg TOXIC EFFECTS : Behavioral - coma REFERENCE : BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 23,552,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 790 mg(base)/kg TOXIC EFFECTS : Details
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5400 ug(base)/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 7,41,1959/1960
TYPE OF TEST : DNA adduct TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 50 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 25 mg/L REFERENCE : AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 2,36,1972
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 5 mg/L REFERENCE : AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 2,36,1972
其他信息
- 易溶于40％的乙醇水溶液中，溶于水。在醚、酮、酯、烃等有机溶剂中几乎不溶解。
