PF-03671148
CAS 1378524-25-4 MFCD478524254
化学结构图
SMILES: Cc1cccc(-n2nccc2-c2ccc3ncn(C)c(=O)c3c2)n1
化学属性
| Mol. Weight | 317.34 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO |
别名和识别编码
| Chemical Name | PF-03671148 |
|---|---|
| Formula | C18H15N5O |
| Synonym | PF03671148; PF03671148; PF 03671148. |
| IUPAC Name | 3-methyl-6-(1-(6-methylpyridin-2-yl)-1H-pyrazol-5-yl)quinazolin-4(3H)-one |
| InChIKey | OWIYYKSTVQMPLM-UHFFFAOYSA-N |
| InChI | InChI=1S/C18H15N5O/c1-12-4-3-5-17(21-12)23-16(8-9-20-23)13-6-7-15-14(10-13)18(24)22(2)11-19-15/h3-11H,1-2H3 |
| Canonical SMILES | O=C1N(C)C=NC2=C1C=C(C3=CC=NN3C4=NC(C)=CC=C4)C=C2 |
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产品应用
- PF-03671148 is a potent ALK inhibitor. PF-03671148 inhibits the expression of fibrotic genes and protein markers both in vitro in human fibroblasts and in vivo in a rat wound repair model. Wound healing is not inhibited by the topical application of the ALK5 inhibitor to the wound. PF-03671148 may have potential utility for the prevention of dermal scarring.
