O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N′,N′-tetramethyluronium tetrafluoroborate O-[(乙氧羰基)氰基亚甲基氨基]-N,N,N′,N′-四甲基脲四氟硼酸酯
CAS 136849-72-4 MFCD00192127
化学结构图
SMILES: CCOC(=O)/C(/C#N)=N\OC(N(C)C)=[N+](C)C.F[B-](F)(F)F
化学属性
| Mol. Formula | C10H17BF4N4O3 |
|---|---|
| Mol. Weight | 328 |
| Melting Point | 144-145 |
| TSCA | No |
别名和识别编码
| Chemical Name | O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N′,N′-tetramethyluronium tetrafluoroborate |
|---|---|
| Synonym | N-[[[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy](dimethylamino)methylene]-N-methyl-methanaminium tetrafluoroborate |
| MDL Number | MFCD00192127 |
| CAS Number | 136849-72-4 |
| Reaxys-RN | 13171579 |
| PubChem Substance ID | 160871063 |
| Chemical Name Translation | O-[(乙氧羰基)氰基亚甲基氨基]-N,N,N′,N′-四甲基脲四氟硼酸酯 |
| Beilstein Registry Number | 13171579 |
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分类
- {SNA} Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling, Phosphonium/Uronium/Formamidinium, Synthetic Reagents
产品应用
- 新型脲正离子型多肽缩合剂，适用于条件苛刻的反应，产物消旋率较低。
相关文献及参考
- 3. Werner Seitz, et al Bioorg. Med. Chem. Lett. 18 , 527-531, (2008)
- 5. Birte Basler J. Org. Chem. 70 , 9798-9808, (2005)
- Low racemization peptide coupling agent: Proc. 21st Eur. Pept. Symp., 1990, E. Giralt, D. Andren Eds., ESCOM, Leiden (1991), p143; Tetrahedron Lett., 33, 6625 (1992). See Appendix 6.
安全信息
GHS Symbol
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P330+P331
- P301+P330+P331+P310
- P303+P361+P353+P310+P363
- P304+P340
- P304+P340+P310
- P305+P351+P338
- P305+P351+P338+P310
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H302 Harmful if swallowed 吞食有害
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
