(4-((4-(Ethylamino)-5-(Trifluoromethyl)Pyrimidin-2-Yl)Amino)-2-Fluoro-5-Methoxyphenyl)(Morpholino)Methanone (4-((4-(乙基氨基)-5-(三氟甲基)嘧啶-2-基)氨基)-2-氟-5-甲氧基苯基)(吗啉代)甲酮
CAS 1351761-44-8 MFCD451761448
化学结构图
SMILES: CCNc1nc(Nc2cc(F)c(C(=O)N3CCOCC3)cc2OC)ncc1C(F)(F)F
化学属性
| Mol. Weight | 443.39535 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | (4-((4-(Ethylamino)-5-(Trifluoromethyl)Pyrimidin-2-Yl)Amino)-2-Fluoro-5-Methoxyphenyl)(Morpholino)Methanone |
|---|---|
| Formula | C19H21F4N5O3 |
| Synonym | GNE7915; GNE 7915; GNE-7915. |
| IUPAC Name | (4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone |
| InChIKey | XCFLWTZSJYBCPF-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H21F4N5O3/c1-3-24-16-12(19(21,22)23)10-25-18(27-16)26-14-9-13(20)11(8-15(14)30-2)17(29)28-4-6-31-7-5-28/h8-10H,3-7H2,1-2H3,(H2,24,25,26,27) |
| Canonical SMILES | O=C(C1=CC(OC)=C(NC2=NC=C(C(F)(F)F)C(NCC)=N2)C=C1F)N3CCOCC3 |
| Chemical Name Translation | (4-((4-(乙基氨基)-5-(三氟甲基)嘧啶-2-基)氨基)-2-氟-5-甲氧基苯基)(吗啉代)甲酮 |
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产品应用
- GNE-7915 is a potent LRRK2 kinase inhibitor, which possess an ideal balance of LRRK2 cellular potency, broad kinase selectivity, metabolic stability, and brain penetration across multiple species. GNE-7915 was reported as a potent (IC50=9 nM) selective (1/187 kinases), brain-penetrant and non-toxic inhibitor of LRRK2.
