CAS 135-09-1 MFCD00057316-Hydroflumethiazide 氢氟噻嗪 TAO{mole}

Hydroflumethiazide 氢氟噻嗪

CAS 135-09-1 MFCD00057316

化学结构图

SMILES: NS(=O)(=O)c1cc2c(cc1C(F)(F)F)NCNS2(=O)=O

化学属性

Mol. Formula	C8H8F3N3O4S2
Mol. Weight	331.31

别名和识别编码

Chemical Name	Hydroflumethiazide
CAS Number	135-09-1
Synonym	3,4-Dihydro-7-sulfamyl-6-trifluoromethyl-2H-1,2,4-benzothiadiazine 3,4-Dihydro-6-(trifluoromethyl)- Dihydroflumethiazide Bristab Bristurin 氢氟噻嗪 Di-ademil
MDL Number	MFCD00057316
PubChem Substance ID	3647
EC Number	205-173-8
Chemical Name Translation	氢氟噻嗪
Wiswesser Line Notation	T66 BSWM EM DHJ HXFFF ISZW
Beilstein Registry Number	0342692
LabNetwork Molecule ID	LN00198008
InChI	InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)

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产品应用

Antihypertensive; diuretic.

安全信息

WGK Germany2

GHS Symbol

Precautionary statements

P342+P311
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Hazard statements

H317 May cause an allergic skin reaction 可能导致皮肤过敏
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难

RTECSDK9625000

Signal word Danger

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；

Hazard Codes Xn

Risk Statements

R42/43

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,629,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1182 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   FMXXAJ French Medicament Patent Document.  (U.S. Patent and Trademark
   Office, Foreign Patents, Washington, DC 20231)  Discontinued.
   Volume(issue)/page/year: #80M

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6280 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 134,273,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &