CAS 13422-55-4 MFCD00082483-Methylcobalamin 甲基钴胺素 TAO{mole}

Methylcobalamin 甲基钴胺素

CAS 13422-55-4 MFCD00082483

化学结构图

SMILES: CC1(C)[C@H](CCC(N)=O)C2N=C1C=C1N=C(C(C)=C3[C@@H](CCC(N)=O)[C@](C)(CC(N)=O)[C@](C)([C@@H]4N=C(C=2C)[C@](C)(CCC(=O)NCC(C)OP([O-])(=O)O[C@@H]2[C@@H](CO)O[C@@H]([C@@H]2O)N2C=NC5C=C(C)C(C)=CC2=5)[C@H]4CC(N)=O)N3[Co+]C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O

化学属性

Mol. Formula	C63H91CoN13O14P
Mol. Weight	1344
Density	0.96
Stability	对光敏感

别名和识别编码

Chemical Name	Methylcobalamin
CAS Number	13422-55-4
Synonym	Methyl Vitamin B12 Methylcobaz 6-二甲基苯并咪唑基)]-β甲钴酰胺 Mecobalamin Methylcobalamin 甲钴胺VB12,Coα-[α-(5 Methycobal Algobaz Cobalt-methylcobalamin 甲基钴胺素 MBL-A MeCbl Methyl vitamin B12 Methyl cobalamine Hitocobamin-M 甲钴胺 Methyl-5,6-dimethylbenzimidazolylcobalamin Methyl-5,6-dimethylbenzimidazolylcobalamin; Vitamin B12 Methyl-B12
MDL Number	MFCD00082483
EC Number	236-535-3
Chemical Name Translation	甲基钴胺素
PubChem Substance ID	253661235
Reaxys-RN	18144941

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产品应用

甲钴胺是一种内源性的辅酶B12，参与一碳单位循环，在由同型半胱氨酸合成蛋氨酸的转甲基反应过程中起重要作用。

安全信息

WGK Germany2

RTECSGG3745000

Storage condition -20°C避光保存 0-10°C

GHS Symbol

Safety Statements

S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Precautionary statements

P296

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10 mg/kg
                          female 14-20 day(s) after conception
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
   Reproductive - Tumorigenic effects - transplacental tumorigenesis
REFERENCE :
   BEBMAE Byulleten' Eksperimental'noi Biologii i Meditsiny.  Bulletin of
   Experimental Biology and Medicine.  For English translation, see BEXBAN.
   (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 101,471,1986

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 22,3939,1988

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TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 4,529,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year:

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 4,529,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 12500 ug/kg
SEX/DURATION            : female 17-21 day(s) after conception
                          lactating female 20 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - sex ratio
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 22,3917,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5500 ug/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
   Reproductive - Effects on Newborn - sex ratio
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 22,3899,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 550 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 22,3899,1988