Lactacystin
CAS 133343-34-7 MFCD01076525
化学结构图
SMILES: CC(=O)N[C@@H](CSC(=O)[C@@]1(NC(=O)[C@H](C)[C@@H]1O)[C@@H](O)C(C)C)C(O)=O
化学属性
| Mol. Formula | C15H24N2O7S |
|---|---|
| Mol. Weight | 376 |
别名和识别编码
| Chemical Name | Lactacystin |
|---|---|
| CAS Number | 133343-34-7 |
| Synonym | Lactacystin N-Acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]-L-cysteine |
| MDL Number | MFCD01076525 |
| PubChem Substance ID | 24896445 |
| Chemical Name Translation |
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分类
- {SNA} Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Calpain and Proteasome Inhibitors, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Endoplasmic Reticulum Stress, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Inh
产品应用
- A selective and potent inhibitor of proteasome-mediated degradation of ubiquitin-tagged proteins. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP: multic
相关文献及参考
- [2]. Savolainen MH, et al. Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activationand shows various phenotypes of Parkinson's disease in young and adult mouse. Exp Brain Res. 2017 Jul;235(7):2189-2202.
- Fenteany, G., et al.: Proc. Natl. Acad. Sci. USA, 91, 3358 (1994),
- Fenteany, G., et al.: Science, 268, 726 (1995),
- [1]. Csizmadia V, et al. Effect of proteasome inhibitors with different chemical structures on the ubiquitin-proteasomesystem in vitro. Vet Pathol. 2010 Mar;47(2):358-67.
- [1]. Csizmadia V, et al. Effect of proteasome inhibitors with different chemical structures on the ubiquitin-proteasomesystem in vitro. Vet Pathol. 2010 Mar;47(2):358-67.
- [2]. Savolainen MH, et al. Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activationand shows various phenotypes of Parkinson's disease in young and adult mouse. Exp Brain Res. 2017 Jul;235(7):2189-2202.
