DARIFENACIN
CAS 133099-04-4 MFCD00896313
化学结构图
SMILES: NC(=O)C([C@H]1CN(CC1)CCC1=CC2CCOC=2C=C1)(C1C=CC=CC=1)C1C=CC=CC=1
化学属性
| Mol. Formula | C28H30N2O2 |
|---|---|
| Mol. Weight | 426.557 |
别名和识别编码
| Chemical Name | DARIFENACIN |
|---|---|
| Chemical Name Translation |
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相关文献及参考
- [2]. Lu XZ, et al. Activation of M3 cholinoceptors attenuates vascular injury after ischaemia/reperfusion by inhibiting the Ca2+/calmodulin-dependent protein kinase II pathway. Br J Pharmacol. 2015 Dec;172(23):5619-33.
- [3]. Miller DW, et al. Evaluation of drug efflux transporter liabilities of darifenacin in cell culture models of the blood-brain and blood-ocular barriers. Neurourol Urodyn, 2011, 30(8), 1633-1638.
- [4]. Yu H, et al.Acetylcholine acts through M3 muscarinic receptor to activate the EGFR signaling and promotes gastric cancer cell proliferation. Sci Rep. 2017 Jan 19;7:40802.
- [5]. Iijima K, et al. Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve. Eur Urol, 2007, 52(3), 842-847.
- [1]. He
- [1]. Hegde SS, et al. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol, 1997, 120(8), 1409-1418.
