CAS 13292-46-1 MFCD00151389-Rifampicin 利福平 TAO{mole}

Rifampicin 利福平

CAS 13292-46-1 MFCD00151389

化学结构图

SMILES: CN1CCN(CC1)/N=C/c1c2NC(=O)C(C)=CC=C[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@H](C=CO[C@@]3(C)Oc4c(c(c(c2O)c(O)c4C)c1O)C3=O)OC |c:16,t:18,38|

化学属性

Mol. Formula	C43H58N4O12
Mol. Weight	822.95
Melting Point	194
Density	1.34

别名和识别编码

Chemical Name	Rifampicin
Synonym	Dione 21-acetate NSC 113926 Rifampicin SV Rimactan Rimactizid Rifaldazin 利福平 Rifampicinum Rifadin Rifaprodin Rifinah Rifagen Rifampicin 3-(4-甲基-1-哌嗪基亚胺甲基)利福霉素SV 甲哌利福霉素 R/AMP Rifampin 8-(4-Methylpiperazinyliminomethyl) rifamycin SV Rifadine Rifobac L-5103 3-(4-甲基-1-哌嗪基亚胺甲基)利福霉素SV 利米定甲哌利福霉素 3-[[(4-methyl-1-piperazinyl)imino]methyl]-rifamycin Rifa {haz Riforal Rifamycin AMP 3-(4-Methylpiperazinyliminomethyl)-rifamycin SV Sinerdol 利米定 Rifoldine Rimactane Archidyn Rimactazid
CAS Number	13292-46-1
PubChem Substance ID	87560354
EC Number	236-312-0
Beilstein Registry Number	5723476
MDL Number	MFCD00151389
Reaxys-RN	5723476
Merck Number	8216
Chemical Name Translation	利福平
InChIKey	JQXXHWHPUNPDRT-WLSIYKJHSA-N
Wiswesser Line Notation	T C6 B65-24- A D E 2BC G& AV LO NO F&VM OU B&U D&UMH&&&TJ DQ GQ IQ JI MI QO1 R1 SOV1 T1 UQ
LabNetwork Molecule ID	LN01374931

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品牌质保精细包装现货库存一流品牌服务

产品应用

抑制DNA的重组和蛋白质插进成熟的病毒颗粒。靠结合RNA聚合酶的β-亚单元抑制RNA合成的起始。

安全信息

GHS Symbol

WGK Germany3

Hazard Codes Xn

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H335 May cause respiratory irritation 可能导致呼吸道刺激
H302 Harmful if swallowed 吞食有害
H319 Causes serious eye irritation 严重刺激眼睛

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

RTECSVJ7000000

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P332+P313
P302+P352+P332+P313+P362+P364
P305+P351+P338+P337+P313
P301+P312+P330
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。

Signal word

Storage condition 0-10 0-10°C 储存温度 -20°C

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8400 mg/kg/60W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   43,293,1978

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 857 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Gastrointestinal - other changes
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   240,2283,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 504 mg/kg/42D-I
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - dyspnea
   Blood - aplastic anemia
REFERENCE :
   AJMEAZ American Journal of Medicine.  (Technical Pub., 875 Third Ave., New
   York, NY 10022) V.1-    1946-  Volume(issue)/page/year: 87,459,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 416 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CMTRAG Chemotherapia.  (Basel, Switzerland)  V.1-12, 1960-67.  For publisher
   information, see CHTHBK.  Volume(issue)/page/year: 12,155,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2120 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ACHTA6 Antibiotica et Chemotherapia (Basel, 1954-70).  (Basel, Switzerland)
   V.1-16, 1954-70.  For publisher information, see ANBCB3.
   Volume(issue)/page/year: 16,316,1970

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 250 mg/L
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Pu

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 250 mg/L
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 22,350,1984

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 ug/kg
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 194

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 100 mg/L
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 79,1101,1982

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 60 ng/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,2819,1983

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 mg/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Vol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 800 mg/kg
SEX/DURATION            : female 9-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   PRTUAX Problemy Tuberkuleza.  Problems of Tuberculosis.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1923-
   Volume(issue)/page/year: 69(2),67,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 2600 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   ACHTA6 Antibiotica et Chemotherapia (Basel, 1954-70).  (Basel, Switzerland)
   V.1-16, 1954-70.  For publisher information, see ANBCB3.
   Volume(issue)/page/year: 16,316,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1400 mg/kg
SEX/DURATION            : female 4-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D:
   Sciences Naturelles.  (Paris, Franc

其他信息

溶解度: 1.3 mg/mL水 pH 4.3、2.5 mg/mL水 pH 7.3、100 mg/mL DMSO。