KRIBB3
CAS 129414-88-6 MFCD00710140
化学结构图
SMILES: CCc1cc(-c2oncc2-c2ccc(OC)cc2)c(O)cc1OC
化学属性
| Mol. Formula | C19H19NO4 |
|---|---|
| Mol. Weight | 325.36 |
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | KRIBB3 |
|---|---|
| Synonym | 5-(5-Ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole KRIBB3 KRIBB3; KRIBB-3; KRIBB 3. |
| MDL Number | MFCD00710140 |
| PubChem Substance ID | 24896001 |
| Chemical Name Translation | |
| Formula | C19H19NO4 |
| IUPAC Name | 4-ethyl-5-methoxy-2-(4-(4-methoxyphenyl)isoxazol-5-yl)phenol |
| InChIKey | BNBHIGLOMVMJDB-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H19NO4/c1-4-12-9-15(17(21)10-18(12)23-3)19-16(11-20-24-19)13-5-7-14(22-2)8-6-13/h5-11,21H,4H2,1-3H3 |
| Canonical SMILES | OC1=CC(OC)=C(CC)C=C1C2=C(C3=CC=C(OC)C=C3)C=NO2 |
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分类
- {SA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, K, Kinase/Phosphatase Biology, Protein Kinase C (PKC), Protein Kinase Inhibitors, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
- {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, K, Kinase/Phosphatase Biology, Protein Kinase C (PKC), Protein Kinase Inhibitors, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
产品应用
- KRIBB3 is novel and potent microtubule inhibitor with potential anticancer activity. KRIBB3 has anti-migratory and anti-invasive activities in MDA-MB-231 cells. KRIBB3 inhibits tumor cell migration and invasion by blocking protein kinase C-dependent phosphorylation of Hsp27 through its direct binding to Hsp27.
安全信息
GHS Symbol
- P301+P310
- H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
- H301 Toxic if swallowed 吞食有毒
- R22 Harmful if swallowed 吞咽有害
