Bis(2-Carboxyethylgermaniumsesquioxide) 二羧乙基三氧化二
CAS 12758-40-6 MFCD00049319
化学结构图
SMILES: OC(=O)CC[Ge](=O)O[Ge](=O)CCC(O)=O
化学属性
| Mol. Formula | C6H10Ge2O7 |
|---|---|
| Mol. Weight | 339.40 |
| TSCA | Yes |
| Melting Point | 320° dec. |
别名和识别编码
| Chemical Name | Bis(2-Carboxyethylgermaniumsesquioxide) |
|---|---|
| Synonym | SK 818 Carboxyethylgermanium sesquioxide 2-Carboxyethylgermasesquioxane 羧乙基锗倍半氧化物(GE-132) Dipropanoic acid germanium sequioxide GE 132 有机锗(Ge-132)，复合锗丙酸，二羧乙基三氧化二锗 Proxigermanium Ge 132 2-(Carboxyethyl)germanium sesquioxide 3,3'-(Dioxodigermoxanylene) dipropanoic acid 羧乙基锗倍半氧化物 Carboxylethylgermanium sesquioxide Bis(carboxyethylgermanium sesquioxide); 3,3'-(1,3-Dioxo-1,3-digermoxanediyl)dipropionic acid Bis-beta-carboxyethylgermanium sesquioxide Propagermanium 3,3'-(Germanoic anhydride) dipropanoic acid Germanate(2-), bis(2-carboxylatoethyl)trioxodi-, dihydrogen |
| MDL Number | MFCD00049319 |
| PubChem Substance ID | 87564292 |
| EC Number | 235-800-0 |
| CAS Number | 12758-40-6 |
| Reaxys-RN | 4141883 |
| Merck Number | 7795 |
| Chemical Name Translation | 二羧乙基三氧化二 |
| Wiswesser Line Notation | QV2-GE-O&O-GE-O&2VQ |
| Beilstein Registry Number | 4141883 |
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分类
- {SNA} Chemical Synthesis, Organogermanium, Organometallic Reagents
产品应用
- 复合锗丙酸有机锗即羧乙基锗倍半氧化物，亦称Ge-132。它是人参、灵芝等名贵中药里的重要而有效的成份，有机锗是制药，功能食品及美容化妆品的优质原料。
相关文献及参考
- Merck: 14,7795
安全信息
- H315 Causes skin irritation 会刺激皮肤
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P302+P352+P332+P313+P362+P364
- P332+P313
- P305+P351+P338+P337+P313
- P302+P350
- P337+P313
- P305+P351+P338
GHS Symbol
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1195,1995
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Skin and Appendages - dermatitis, other (after systemic exposure) REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1195,1995
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,19,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION
TYPE OF TEST : Micronucleus test ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 5600 mg/kg REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,289,1990
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 20 gm/kg REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,289,1990
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 11 gm/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - other measures of fertility Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,227,1990
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 44 gm/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - sex ratio REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,227
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 78 gm/kg
SEX/DURATION : female 17 day(s) after conception - 21 day(s)
post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 24,263,1990其他信息
- 无味、不溶于乙醇、乙醚、可容于碱、水中最大溶解度为10.8g/L，饱和水溶液的PH＝2.5～2.6。
