MPT0B098
CAS 1254363-89-7 MFCD354363897
化学结构图
SMILES: COc1ccc(S(=O)(=O)N2CCc3cccc(-c4ccncc4)c32)cc1
化学属性
| Mol. Weight | 366.43 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | MPT0B098 |
|---|---|
| Formula | C20H18N2O3S |
| Synonym | MPT0B098 |
| IUPAC Name | 1-((4-methoxyphenyl)sulfonyl)-7-(pyridin-4-yl)indoline |
| InChIKey | AGYCYVPAEQVWJT-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H18N2O3S/c1-25-17-5-7-18(8-6-17)26(23,24)22-14-11-16-3-2-4-19(20(16)22)15-9-12-21-13-10-15/h2-10,12-13H,11,14H2,1H3 |
| Canonical SMILES | O=S(N1CCC2=C1C(C3=CC=NC=C3)=CC=C2)(C4=CC=C(OC)C=C4)=O |
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产品应用
- MPT0B098 is a potent microtubule inhibitor through binding to the colchicine-binding site of tubulin. MPT0B098 is active against the growth of various human cancer cells, including chemoresistant cells with IC50 values ranging from 70 to 150 nmol/L. MPT0B098 arrests cells in the G2–M phase and subsequently induces cell apoptosis. In addition, MPT0B098 effectively suppresses VEGF-induced cell migration and capillary-like tube formation of HUVECs. Distinguished from other microtubule inhibitors, MPT0B098 not only inhibited the expression levels of HIF-1α protein but also destabilized HIF-1α mRNA. The mechanism of causing unstable of HIF-1α mRNA by MPT0B098 is through decreasing RNA-binding protein, HuR, translocation from the nucleus to the cytoplasm. Notably, MPT0B098 effectively suppresses tumor growth and microvessel density of tumor specimens in vivo. Taken together, our results provide a novel mechanism of inhibiting HIF-1α of a microtubule inhibitor MPT0B098. MPT0B098 is a promisi
