CAS 125-84-8 MFCD00010122-DL-Aminoglutethimide 氨鲁米特 TAO{mole}

DL-Aminoglutethimide 氨鲁米特

CAS 125-84-8 MFCD00010122

化学结构图

SMILES: CCC1(c2ccc(N)cc2)CCC(=O)NC1=O

化学属性

Mol. Formula	C₁₃H₁₆N₂O₂
Mol. Weight	232.28
Melting Point	151-153ºC
Solubility	H2O: 0.2 mg/mL, slightly soluble

别名和识别编码

Chemical Name	DL-Aminoglutethimide
CAS Number	125-84-8
Synonym	(+/-)-P-AMINOGLUTETHIMIDE (RS)-2-ETHYL-2-(4-AMINO-PHENYL)-GLUTARIMIDE (RS)-3-(4-AMINO-PHENYL)-3-ETHYL-PIPERIDINE-2,6-DIONE (RS)-3-ETHYL-3-(4-AMINO-PHENYL)-2,6-DIOXO-PIPERIDINE 2,6-Piperidinedione, 3-(4-aminophenyl)-3-ethyl- 2-(p-Aminophenyl)-2-ethylglutarimide 2-(p-Aminophenyl)-2-ethylglutarimide2,6-piperidinedione, 3-(4-aminophenyl)-3-ethyl- 2-(p-aminophenyl)-2-ethyl-glutarimid 3-(4-AMINOPHENYL)-3-ETHYL-2,6-PIPERIDINEDIONE 3-(4-AMINOPHENYL)-3-ETHYLPIPERIDINE-2,6-DIONE 3-(4-Aminophenyl)-3-ethyl-2,6-Piperidinedione 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione 3-(4-aminophenyl)-3-ethyl-6-piperidinedione 3-(p-Aminophenyl)-3-ethylpiperidine-2,6-dione 3-(p-Aminophenyl)-3-ethylpiperidine-2,6-dione 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione 3-Ethyl-3-(p-aminophenyl)
PubChem Substance ID	2145
EC Number	204-756-4
MDL Number	MFCD00010122
Chemical Name Translation	氨鲁米特
Merck Number	440
Wiswesser Line Notation	T6VMVTJ D2 DR DZ
Beilstein Registry Number	0210656
LabNetwork Molecule ID	LN00222781
InChI	InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)

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分类

A to C, A-AM, Antitumor Agents, Approved Therapeutics/Drug Candidates, Aromatase Inhibitors, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cytochrome P450, Cytokines, Growth Factors and Hormones, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Hormones, Novartis, Other Steroid Products, Steroid Hormones, Tumor Growth Regulation
{SNA} A to C,
{SNA} A to C, A-AM, Antitumor Agents, Approved Therapeutics/Drug Candidates, Aromatase Inhibitors,
{SNA} A to C,

产品应用

An aromatase inhibitor. Also blocks adrenal steroidogenesis.

安全信息

GHS Symbol

WGK Germany3

Hazard Codes Xi

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

RTECSMA4026950

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338

Signal word Warning

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Packing GroupIII

Hazard Class6.1(b)

Storage condition -20°C 2-8°C

UN Number 3249

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 20500 mg/kg/94W-I
TOXIC EFFECTS :
   Blood - agranulocytosis
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   291,970,1985

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 21 mg/kg/3D-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   105,633,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 625 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - antipsychotic
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 18,736,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 3630 mg/kg
SEX/DURATION            : female 1-35 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   AJDCAI American Journal of Diseases of Children.  (AMA, 535 N. Dearborn St.,
   Chicago, IL 60610) V.1-80(3), 1911-50; V.100-    1960-
   Volume(issue)/page/year: 124,421,1972

其他信息

储运特性:库房通风低温干燥
MOL 文件:125-84-8.mol
毒性分级:中毒
Sigma Aldrich:125-84-8(sigmaaldrich)
MSDS 信息:3-(4-Aminophenyl)-3-ethyl-2,6-Piperidinedione(125-84-8).msds
TCI Shanghai:DL-氨鲁米特 DL-Aminoglutethimide,>;98.0%(LC)(T)(125-84-8)
color:white
急性毒性:腹腔-小鼠LD50:625 毫克/公斤
灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
可燃性危险特性:可燃;燃烧产生有毒氮氧化物烟雾
类别:有毒物品