N-(5-(5-Cyanothiophen-2-Yl)-2-Methylphenyl)-4-Methylbenzenesulfonamide N-(5-(5-氰基噻吩-2-基)-2-甲基苯基)-4-甲基苯磺酰胺
CAS 1233948-35-0 MFCD333948350
化学结构图
SMILES: Cc1ccc(S(=O)(=O)Nc2cc(-c3ccc(C#N)s3)ccc2C)cc1
化学属性
| Mol. Weight | 368.47 |
|---|---|
| Appearance | Yellow solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | N-(5-(5-Cyanothiophen-2-Yl)-2-Methylphenyl)-4-Methylbenzenesulfonamide |
|---|---|
| Formula | C19H16N2O2S2 |
| Synonym | ELR510444; ELR-510444; ELR 510444. |
| IUPAC Name | N-(5-(5-cyanothiophen-2-yl)-2-methylphenyl)-4-methylbenzenesulfonamide |
| InChIKey | GRYXROIHHXHFND-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H16N2O2S2/c1-13-3-8-17(9-4-13)25(22,23)21-18-11-15(6-5-14(18)2)19-10-7-16(12-20)24-19/h3-11,21H,1-2H3 |
| Canonical SMILES | O=S(C1=CC=C(C)C=C1)(NC2=CC(C3=CC=C(C#N)S3)=CC=C2C)=O |
| Chemical Name Translation | N-(5-(5-氰基噻吩-2-基)-2-甲基苯基)-4-甲基苯磺酰胺 |
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产品应用
- ELR510444 is a potent microtube disruptor with potential anticancer activity. ELR510444 has potent microtubule-disrupting activity, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells. ELR510444 potently inhibited cell proliferation with an IC(50) value of 30.9 nM in MDA-MB-231 cells, inhibited the rate and extent of purified tubulin assembly, and displaced colchicine from tubulin, indicating that the drug directly interacts with tubulin at the colchicine-binding site.
相关文献及参考
- [2]. Carew JS, et al. ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinoma. PLoS One. 2012;7(1):e31120.
- [1]. Risinger AL, et al. ELR510444, a novel microtubule disruptor with multiple mechanisms of action. J Pharmacol Exp Ther. 2011 Mar;336(3):652-60.
- [1]. Risinger AL, et al. ELR510444, a novel microtubule disruptor with multiple mechanisms of action. J Pharmacol Exp Ther. 2011 Mar;336(3):652-60.
- [2]. Carew JS, et al. ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinoma. PLoS One. 2012;7(1):e31120.
