Alosetron Hydrochloride 盐酸阿洛司琼
CAS 122852-69-1 MFCD22852691
化学结构图
SMILES: CN1C2C=CC=CC=2C2=C1CCN(CC1N=CNC=1C)C2=O
化学属性
| Mol. Weight | 330.82 |
|---|---|
| Mol. Formula | C17H18N4O·HCl |
别名和识别编码
| CAS Number | 122852-69-1 |
|---|---|
| Chemical Name | Alosetron Hydrochloride |
| Synonym | 2,3,4,5-Tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-1H-pyrido[4,3-b]indol-1-one Hydrochloride GR 68755 GR 68755X Lotronex |
| Chemical Name Translation | 盐酸阿洛司琼 |
| MDL Number | MFCD03453647 |
| Merck Number | 308 |
| PubChem Substance ID | 354335545 |
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分类
- Heterocycles
- Nucleotides
- Bases & Related Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- Serotonin 5HT3-receptor antagonist. Used in treatment of irritable bowel syndrome.
相关文献及参考
- [2]. Lucak SL.
- [3]. Lewis JH.
- [4]. Turgeon DK, Tayeh N, Fontana RJ.
- [5]. Miller DP, Alfredson T, Cook SF, Sands BE, Walker AM.
- [6]. Balfour JA, Goa KL, Perry CM. Alosetron. Drugs. 2000;59(3):511-520.
- [7]. Motavallian A, et al. Anti-inflammatory effects of alosetron mediated through 5-HT3 receptors on experimental colitis. Res Pharm Sci. 2019;14(3):228-236.
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- Acute hepatitis associated with alosetron (Lotronex).
- Acute hepatitis associated with alosetron (Lotronex).
- Alosetron for severe diarrhea-predominant irritable bowel syndrome: safety and efficacy in perspective.
- Alosetron for severe diarrhea-predominant irritable bowel syndrome: safety and efficacy in perspective.
- Am J Gastroenterol. 2003 May;98(5):1117-22.
- Am J Gastroenterol. 2003 May;98(5):1117-22.
- Expert Rev Gastroenterol Hepatol. 2010 Feb;4(1):
- Expert Rev Gastroenterol Hepatol. 2010 Feb;4(1):13-29.
安全信息
GHS Symbol
- H301 Toxic if swallowed 吞食有毒
- P301+P310+P330
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
