SKLB1002 2-((6,7-二甲氧基喹唑啉-4-基)硫基)-5-甲基-1,3,4-噻二唑
CAS 1225451-84-2 MFCD325451842
化学结构图
SMILES: COc1cc2ncnc(Sc3nnc(C)s3)c2cc1OC
化学属性
| Mol. Weight | 320.39 |
|---|---|
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | 2-((6,7-二甲氧基喹唑啉-4-基)硫基)-5-甲基-1,3,4-噻二唑 |
|---|---|
| Chemical Name | SKLB1002 |
| Formula | C13H12N4O2S2 |
| Synonym | SKLB1002; SKLB 1002; SKLB1002. |
| IUPAC Name | 2-((6,7-dimethoxyquinazolin-4-yl)thio)-5-methyl-1,3,4-thiadiazole |
| InChIKey | RQVGFDBMONQTBC-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H12N4O2S2/c1-7-16-17-13(20-7)21-12-8-4-10(18-2)11(19-3)5-9(8)14-6-15-12/h4-6H,1-3H3 |
| Canonical SMILES | CC1=NN=C(SC2=C3C=C(OC)C(OC)=CC3=NC=N2)S1 |
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产品应用
- SKLB1002 is a new potent VEGFR2 inhibitor, which could significantly inhibit HUVEC proliferation, migration, invasion, and tube formation. Western blot analysis was conducted, which indicated that SKLB1002 inhibited VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal-regulated kinase, focal adhesion kinase, and Src. In vivo zebrafish model experiments showed that SKLB1002 remarkably blocked the formation of intersegmental vessels in zebrafish embryos. SKLB1002 inhibits angiogenesis and may be a potential drug candidate in anticancer therapy.
