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• {S
• {Chemicalbook} 农药中间体: 杀菌剂中间体: 三唑类杀菌剂
• {SNA} Alphabetical Listings, Flavors and Fragrances, Halal Certified Products, Kosher Certified Products, O-Z, Q-Z
• {SNA} Allium cepa (Onion), Allium sativum (Garlic), Armoracia rusticana (Horseradish), Aspalathus linearis (Rooibos tea), Building Blocks,

产品应用

• 有机合成。制造香料。

相关文献及参考

• [2]. Amin FU, et al. Vanillic acid attenuates Aβ 1-42 -induced oxidative stress and cognitive impairment in mice. Sci Rep. 2017 Jan 18;7:40753.
• Merck: 14,9931
• Merck: 14,9931 Beilstein:10,392
• Ohta, T., et al.: Food Chem. Toxicol., 24, 51 (1986),
• Santos, J., et al.: Mutat. Res., 444, 355 (1999),
• Zhou, Y., et al.: Biochem. Pharmacol., 42, 1177 (1991),
• [1]. Calixto-Campos C, et al. Vanillic acid Inhibits Inflammatory Pain by Inhibiting Neutrophil Recruitment, Oxidative Stress, Cytokine Production, and NFκB Activation in Mice. J Nat Prod. 2015 Aug 28;78(8):1799-808.
• [1]. Calixto-Campos C, et al. Vanillic acid Inhibits Inflammatory Pain by Inhibiting Neutrophil Recruitment, Oxidative Stress, Cytokine Production, and NFκB Activation in Mice. J Nat Prod. 2015 Aug 28;78(8):1799-808.
• [2]. Amin FU, et al. Vanillic acid attenuates Aβ 1-42 -induced oxidative stress and cognitive impairment in mice. Sci Rep. 2017 Jan 18;7:40753.

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2691 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 104,793,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5020 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
   (Paris, France)  V.1-261, 1835-1965.  For publisher information, see CRASEV.
    Volume(issue)/page/year: 243,609,1956

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   29,1275,1980

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 50 gm/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   14,251,1981

其他信息

• 用途二:有机合成。制造香料。
• 用途一:戊酸是制备杀菌剂己唑醇的原料。
• Sigma Aldrich:121-34-6(sigmaaldrich)
• 香草酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw050002 香草酸;香荚兰酸;4-羟基-3-甲氧基苯甲酸 25g 90元 2011/04/16 V0017 香草酸 Vanillic Acid 25G 559元 2011/04/16 V0017 香草酸 Vanillic Acid 100G 1420元
• FEMA:3988
• TCI Shanghai:4-羟基-3-甲氧基苯甲酸 Vanillic Acid,>;98.0%(T)(121-34-6)
• 无气味。能升华而不分解。溶于860份水，易溶于乙醇，溶于乙醚。不与三氯化铁生成颜色。其盐类易溶于水。有刺激性。
• MSDS 信息:4-Hydroxy-3-methoxybenzoic acid(121-34-6).msds
• Hazard Note:Irritant
• 上游原料:氧氯化硫 --> 三氯化磷 --> 1-戊醇 --> 正戊酸 --> 丁烯
• 海关编码:29189090
• Acros Organics:4-羟基-3-甲氧基苯甲酸 /香草酸 4-Hydroxy-3-methoxybenzoic acid, 98.5+%(121-34-6)
• Alfa Aesar:香草酸,98% Vanillic acid, 98%(121-34-6)
• 理化性质:化学名称为“4-羟基-3-甲氧基苯甲酸”，分子式C8H8O4，分子量168.14，白色针状晶体，无气味，能升华，不分解。熔点210℃。易溶于乙醇，可溶于乙醚，微溶于水。香草酸与三氯化铁作用不显色。制法：以香草醛为原料通过氧化(氧化银)或碱熔(氢氧化钾，240℃以下)可得，或从3，4-二甲氧基苯甲酸部分脱去甲基而得。用途：作试剂，制香料。
• MOL 文件:121-34-6.mol
• 方法一:其制备方法是可以用1-戊醇电解氧化或用甲酸和丁烯反应而制得。反应方程式：CH 3 (CH 2 ) 3 CH 2 OH[电解]→[O 2 ]CH 3 (CH 2 ) 3 COOH CH 3 CH 2 CH＝CH 2 +HCOOH→CH 3 (CH 2 ) 3 COOH 戊酸和氯化亚砜或三氯化磷反应可生成相应的戊酰氯。CH 3 (CH 2 ) 3 COOH+SOCl 2 →CH3(CH 2 ) 3 COCl+SO 2 ↑+HCl↑