CAS 120-71-8 MFCD00007815-2-Methoxy-5-methylaniline 2-甲氧基-5-甲基苯胺 TAO{mole}

2-Methoxy-5-methylaniline 2-甲氧基-5-甲基苯胺

CAS 120-71-8 MFCD00007815

化学结构图

SMILES: COc1ccc(C)cc1N

化学属性

Mol. Formula	C8H11NO
Mol. Weight	137
Boiling Point	235
Melting Point	50-52
Density	1.368
Vapor Density	4.7 (vs air)
Flash Point	111 ºC
Solubility	略溶于热水.

别名和识别编码

Chemical Name	2-Methoxy-5-methylaniline
CAS Number	120-71-8
Alfabeta Name	METHOXYMETHYLANILINE 25---
MDL Number	MFCD00007815
Synonym	2-Amino-p-cresolmethylether 2-甲氧基-5-甲基苯胺;对甲酚定;甲氧基克利西丁;克利西丁;2-氨基-4-甲基苯甲醚;邻氯基对甲基苯甲醚 P- 3-氨基对甲苯甲醚 3-氨基对甲苯甲醚 3-Amino-p-cresol methyl ether 6-甲氧基-间甲苯胺 2-AMINO-4-METHYLANISOLE p-Cresidine 3-Methyl-6-methoxyaniline 5-Methyl-o-anisidine 1-AMINO-2-METHOXY-5-METHYLBENZENE C.I. Azoic Red 83 5-Methyl-o-anisidine; p-Cresidine; 6-Methoxy-m-toluidine; C.I. Azoic Red 83 P-CRESIDINE 3-AMINO-4-METHOXYTOLUENE 4-Methyl-2-aminoanisole p-Kresidi 甲氧基克利西丁 Cresidine 2-甲氧基-5-甲基苯胺 4-METHYL-O-ANISIDINE AKOS BBS-00003649 3-AMINO-P-CRESOL METHYL ETHER 6-METHOXY-M-TOLUIDINE 2-METHOXY-5-METHYLANILINE 4-Methoxy-m-toluidine LABOTEST-BB LTBB000667 2-Amino-4-methylanisole c.i. azoic red 83 2-Methoxy-5-methylbenzenamine Krezidine NCI-C02982 2-氨甲氧基间甲苯胺 3-Amino-4-methoxytoluene {Che 克利西定 5-甲鄰甲氧苯胺 4-METHOXY-M-TOLUIDINE CRESIDINE 5-METHYL-O-ANISIDINE 2-Amino-p-cresol methyl ether 对甲酚定 2-胺對甲苯基甲基醚邻氯基对甲基苯甲醚 m-Amino-p-cresol, methyl ester 邻氨基对甲苯甲醚 2-Methoxy-5-methy 1-Amino-2-methoxy-5-methylbenzene 2-Amino-4-methylphenolmethylether 5-甲基-邻茴香胺 6-甲氧基-间甲苯胺 3-氨基-4-甲氧基
PubChem Substance ID	8445
EC Number	204-419-1
Beilstein Registry Number	637071
Reaxys-RN	637071
Chemical Name Translation	2-甲氧基-5-甲基苯胺
Wiswesser Line Notation	ZR C1 FO1
LabNetwork Molecule ID	LN00127542
InChI	InChI=1S/C8H11NO/c1-6-3-4-8(10-2)7(9)5-6/h3-5H,9H2,1-2H3

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分类

{SNA} 2002/61/EC, All alphabetical sorted, Alpha Sort, Alphabetical Index of Analytical Standards, Amines, A
2002/61/EC, Alpha Sort, Alphabetic, Amines, Analytical Standards, Analytical/Chromatography, Aromatics, Aryl Amines MAK III, Category 2, Chemical Class, Chromatography, Environmental Standards, European Community: ISO, DIN and DL 152, Food & Beverage Standards, Food Dyes, Food Residue Analysis, M, META - METH, Method Specific, Oeko-Tex Standard 100, Volatiles/ Semivolatiles

产品应用

本品是以种染料中间体。在直接染料方面用于合成C.I.29050；29065；27885等，在酸性染料方面用于合成C.I.14940；14965等，还用于制造分散大红GC；直接耐晒蓝3RLL；直接黑D；活性黄棕K-GR；阳离子黄4G等。

安全信息

Warnings 危化品目录(2015) IRRITANT

GHS Symbol

WGK Germany3

Hazard statements

H302 Harmful if swallowed 吞食有害
H350 May cause cancer 可能致癌
H319 Causes serious eye irritation 严重刺激眼睛

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes T T,Xi

RTECSBZ6720000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312+P330
P302+P350
P302+P352+P332+P313+P362+P364
P305+P351+P338
P305+P351+P338+P337+P313
P308+P311
P308+P313
P332+P313
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Risk Statements

R22 Harmful if swallowed 吞咽有害
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R45 May cause cancer 可能致癌

Storage condition 充氩保存

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 364 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Brain and Coverings - tumors
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-142,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 355 gm/kg/92W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-142,1979

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2961 gm/kg/92W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 27,91,1982

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3640 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HURC** Huntingdon Research Center Reports.  (Box 527, Brooklandville, MD
   21022)  Volume(issue)/page/year: -,-,1972

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 2 mg/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7(Suppl
   5),1,1985

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 62500 ng
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7(Suppl
   5),1,1985

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 595 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 412,155,1998

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 31 ug/plate
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1981-
   Volume(issue)/page/year: 1,190,1981

Restrict 危险品

其他信息

急性毒性:口服-大鼠 LD50: 1450 毫克/公斤
下游产品:直接混纺蓝D-3GL --> 直接混纺黄D-3RNL --> 活性黄84 --> 直接绿26 --> 直接紫9 --> 直接黄 RL --> 直接灰D --> C.I.直接紫51 --> 直接红 6BL --> 直接蓝 3RL --> 直接黄L-5R --> 3-氨基-4-甲氧基甲苯-6-磺酸
毒性分级:中毒
Acros Organics:2-甲氧基-5-甲基苯胺 2-Methoxy-5-methylaniline, 95%(120-
刺激数据:皮肤-兔子 500 毫克/24小时轻度; 眼睛-兔子 100 毫克/24小时中度
图谱信息:2-甲氧基-5-甲基苯胺(120-71-8)红外图谱(IR1) 2-甲氧基-5-甲基苯胺(120-71-8)红外图谱(IR2) 2-甲氧基-5-甲基苯胺(120-71-8)红外图谱(IR3) 2-甲氧基-5-甲基苯胺(120-71-8)核磁图( 13 CNMR) 2-甲氧基-5-甲基苯胺(120-71-8)核磁图( 1 HNMR) 2-甲氧基-5-甲基苯胺(120-71-8)质谱(MS)
MOL 文件:120-71-8.mol
类别:有毒物品
溶于醇，醚，氯仿及稀盐酸中，难溶于水，不溶于苯。
用途三:本品是以种染料中间体。在直接染料方面用于合成C.I.29050；29065；27885等，在酸性染料方面用于合成C.I.14940；14965等，还用于制造分散大红GC；直接耐晒蓝3RLL；直接黑D；活性黄棕K-GR；阳离子黄4G等。
用途二:本品是一种染料中间体。
蒸气密度:4.7 (vs air)
2-甲氧基-5-甲基苯胺价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 M0115 2-甲氧基-5-甲基苯胺 2-Methoxy-5-methylaniline 25G 246元 2014/06/02 M0115 2-甲氧基-5-甲基苯胺 2-Methoxy-5-methylaniline 500G 1810元 2010/06/21 332080050 2-甲氧基-5-甲基苯胺
方法一:1.由对氯甲苯硝化、甲氧基化、还原而得。在15-20℃将混酸加入对氯甲苯中，在30℃搅拌2h，用水稀释，分离废酸，水洗得4-氯-3-硝基甲苯（收率30.6%）和4-氯-2-硝基甲苯（收率56.7%），用分馏和结晶法将两者分离，得4-氯-3-硝基甲苯。将其与甲醇及甲醇钠溶液反应，用硫酸中和分离，得3-硝基-4-甲氧基甲苯，收率85.6
Sigma Aldrich:120-71-8(sigmaaldrich)
储运特性:库房通风低温干燥; 与食品原料分开储运
F:9
灭火剂:雾状水、二氧化碳、砂土、干粉
用途一:适用于直接、分散、活性染料的合成
TCI Shanghai:2-甲氧基-5-甲基苯胺 2-Methoxy-5-methylaniline,>;98.0%(GC)(T)(1
上游原料:氢氧化钠 --> 硫酸二甲酯 --> 硫化钠 --> 对氯甲苯 --> 甲醇钠溶液 --> 4-氯-2-硝基甲苯 --> 对甲苯甲醚 --> 3-硝基-4-氯甲苯 --> N-苄基二乙胺
MSDS 信息:邻氨基对甲苯甲醚(120-71-8).msds
方法一:1.由对氯甲苯硝化、甲氧基化、还原而得。在15-20℃将混酸加入对氯甲苯中，在30℃搅拌2h，用水稀释，分离废酸，水洗得4-氯-3-硝基甲苯（收率30.6%）和4-氯-2-硝基甲苯（收率56.7%），用分馏和结晶法将两者分离，得4-氯-3-硝基甲苯。将其与甲醇及甲醇钠溶液反应，用硫酸中和分离，得3-硝基-4-甲氧基甲苯，收率85.6%。用水、铁粉、甲酸还原后，再用溶剂汽油多次萃取蒸馏而得。2.由对甲酚硝化得到2-硝基-4-甲酚，再与硫酸二甲酯甲基化为3-硝基-4-对甲氧基甲苯，最