2-(3,4-Dihydroxybenzylidene)Malononitrile 2-(3,4-二羟基亚苄基)丙二腈
CAS 118409-57-7 MFCD00133899
化学结构图
SMILES: N#CC(=CC1=CC(O)=C(O)C=C1)C#N
化学属性
| Mol. Formula | C10H6N2O2 |
|---|---|
| Mol. Weight | 186 |
| TSCA | No |
别名和识别编码
| Chemical Name | 2-(3,4-Dihydroxybenzylidene)Malononitrile |
|---|---|
| CAS Number | 118409-57-7 |
| Synonym | (3,4-Dihydroxybenzylidene)-malononitrile, RG-50810 (3,4-Dihydroxybenzylidene)malononitrile RG-50810 Tyrphostin 23 Tyrphostin AG-18 |
| MDL Number | MFCD00133899 |
| PubChem Substance ID | 354334883 |
| Chemical Name Translation | 2-(3,4-二羟基亚苄基)丙二腈 |
| Reaxys-RN | 3130787 |
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分类
- {SNA} Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Epidermal Growth Factor Receptor (EGFR), Kinase/Phosphatase Biology, P to Q, Protein Kinase Inhibitors, Protein kinase, tyrosine, EGF receptor, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors, T, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
- Inhibitors; Tyrosine Kinase Inhibitors
- {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Epidermal Gr
产品应用
- A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM).
相关文献及参考
- Lyall, R. M., et al.: J. Biol. Chem., 264, 14503 (1989),
安全信息
- H371 May cause damage to organs 可能导致器官损伤
GHS Symbol
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P308+P311
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
