Limonin 吴茱萸内酯
CAS 1180-71-8 MFCD00075922
化学结构图
SMILES: CC1(C)O[C@H]2CC(=O)OC[C@@]23[C@H]1CC(=O)[C@]1(C)[C@@H]3CC[C@@]2(C)[C@H](c3ccoc3)OC(=O)[C@H]3O[C@]321
化学属性
| Mol. Formula | C26 H30 O8 |
|---|---|
| Mol. Weight | 470.51 |
| Density | 1.39 |
| Melting Point | 298 |
| Boiling Point |
别名和识别编码
| Chemical Name | Limonin |
|---|---|
| Synonym | 11H,13H-Oxireno[d]pyrano[4',3':3,3a]isobenzofuro[5,4-f][2]benzopyran-4,6,13(2H,5aH)-trione, 8-(3-furanyl)decahydro-2,2,4a,8a-tetramethyl-, (2aR,4aR,4bR,5aS,8S,8aS,10aR,10bR,14aS)- 11H,13H-Oxireno[d]pyrano[4',3':3,3a]isobenzofuro[5,4-f][2]benzopyran-4,6,13(2H,5aH)-trione, 8-(3-furanyl)decahydro-2,2,4a,8a-tetramethyl-, [2aR-(2aα,4aβ,4bR*,5aα,8α,8aα,10aα,10bR*,14aα)]- 11H,13H-Oxireno[d]pyrano[4',3':3,3a]isobenzofuro[5,4-f][2]benzopyran-4,6,13(2H,5aH)-trione, 8-(3-furyl)decahydro-2,2,4a,8a-tetramethyl- 7,16-dioxo-7,16-dideoxylimondiol Limonin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} obaculactone {} {} {} {} {} {} {} {} {} {} {PubChem} limonin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} obaculactone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { |
| MDL Number | MFCD00075922 |
| PubChem Substance ID | 179651 |
| CAS Number | 1180-71-8 |
| Chemical Name Translation | 吴茱萸内酯 |
| Reaxys-RN | 1695716 |
| Merck Number | 5494 |
| Beilstein Registry Number | 1695716 |
| LabNetwork Molecule ID | LN02184134 |
| InChI | InChI=1S/C26H30O8/c1-22(2)15-9-16(27)24(4)14(25(15)12-31-18(28)10-17(25)33-22)5-7-23(3)19(13-6-8-30-11-13)32-21(29)20-26(23,24)34-20/h6,8,11,14-15,17,19-20H,5,7,9-10,12H2,1-4H3/t14-,15-,17-,19-,20+,23-,24-,25+,26+/m0/s1 |
| EC Number |
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信息真实价格透明
资金保障
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现货库存
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分类
- {SNA} Alphabetical, Analytical Standards, Citrus, I - M, Phytochemicals Standards, Standards by Plant Genus, 分析/色
- {SNA} Anti-proliferative Agents, Application Index, Biochemicals and Reagents, Cancer Research, Cell Signaling Enzymes, Chemopreventive Agents, Enzymes, Inhibitors, and Substrates, HIV Protease Inhibitor, HIV Protease Reagents & Envelope Proteins, Nutrition Research, Phytochemicals by Chemical Classi
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Citrus, Life Sciences Standards, Phytopharma Standards, Standards by Plant Genus
产品应用
- 对几个肿瘤细胞系具有抗增殖、抗凋亡活性，并抑制氧化偶氮甲烷（azoxymethane）诱发的大鼠结肠癌。依靠抑制HIV - 1蛋白酶活性，抑制HIV - 1病毒在单核细胞，巨噬细胞和单核细胞的复制，
相关文献及参考
- [2]. Kotamballi N. Chidambara Murthy, Jayaprakasha, Vinod Kumar, et al. Citrus Limonin and Its Glucoside Inhibit Colon Adenocarcinoma Cell Proliferation through Apoptosis. J. Agric. Food Chem., 2011, 59 (6):2314-2323.
- [3]. Mahmoud Zaki El-Readi, Dalia Hamdana, Nawal Farrag, et al. Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines. European Journal of Pharmacology. 2010,626 (2-3): 139-145.
- [4]. Battinelli L, Mengoni F, Lichtner M, et al. Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells. Planta Med. 2003 Oct;69(10):910-3.
- [5]. Tanaka T, Kohno H, Tsukio Y, et al. Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats. Biofactors. 2000;13(1-4):213-8.
- Battinelli, L., et al., Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells. Planta Med. 69
安全信息
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P264+P265
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P352
- P302+P352+P332+P313+P362+P364
- P305+P351+P338
- P305+P351+P338+P337+P313
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P332+P313
- P332+P317
- P337+P313
- P337+P317
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- P362+P364
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
其他信息
- 柠檬苦素是一种三萜苷元(triterpenoid aglycone),来自于柑桔类水果.
