CKI-7 CKI-7
CAS 1177141-67-1 MFCD00897689
化学结构图
SMILES: NCCNS(=O)(=O)C1C=CC(Cl)=C2C=CN=CC=12
化学属性
| Mol. Formula | C11H14Cl3N3O2S |
|---|---|
| Mol. Weight | 359 |
别名和识别编码
| Chemical Name | CKI-7 |
|---|---|
| Synonym | CKI-7 dihydrochloride N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide dihydrochloride |
| CAS Number | 1177141-67-1 |
| PubChem Substance ID | 24724430 |
| MDL Number | MFCD00897689 |
| Chemical Name Translation | CKI-7 |
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分类
- Bioactive Small Molecules, CI-CY, Casein Kinase (CK), Cell Biology, Cell Signaling and Neuroscience, Glycogen Synthase Kinase & Casein Kinase (GSK & CK), Kinase/Phosphatase Biology, Protein Kinase Inhibitors, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
- {SNA} Bioactive Small Molecule Alphabetical Index, CI-CZ, Casein Kinase (CK), Glycogen Synthase Kinase & Ca
- {SNA} Bioactive Small Molecules, CI-CY, Casein Kinase (CK), Cell Biology, Cell Signaling and Neuroscience, Glycogen Synthase Kinase & Casein Kinase (GSK & CK), Kinase/Phosphatase Biology, Protein Kinase Inhibitors, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
相关文献及参考
- [2]. Mark G. Frattini, et al. Small Molecule Inhibition of Cdc7, a Key Cell Cycle Regulator and Novel Therapeutic Target, Successfully Inhibits Leukemia Cell Growth in Vitro and in Vivo. Blood (2008) 112 (11): 2668.
- [3]. Chijiwa T, et al. A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide, and affinity purification of casein kinase I from bovine testis. J Biol Chem. 1989 Mar 25;264(9):4924-7.
- [4]. Rena G, et al. D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 2004 Jan;5(1):60-5.
- Rena, G., et al. , D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO J. Rep. 5 , 60-65, (2004) 摘要
- [1]. Osakada F, et al. In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J Cell Sci. 2009 Sep 1;122(Pt
安全信息
GHS Symbol
- H301 Toxic if swallowed 吞食有毒
- P301+P310
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R25 Toxic if swallowed 吞咽有毒
