(R)-3-(3-(4-Fluorophenylsulfonamido)-3,4-Dihydro-1H-Carbazol-9(2H)-Yl)Propanoic Acid (R)-3-(3-(4-氟苯基磺酰胺基)-3,4-二氢-1H-咔唑-9(2H)-基)丙酸
CAS 116649-85-5 MFCD00887606
化学结构图
SMILES: O=C(O)CCn1c2c(c3ccccc31)C[C@H](NS(=O)(=O)c1ccc(F)cc1)CC2
化学属性
| Mol. Formula | C21H21FN2O4S |
|---|---|
| Mol. Weight | 416 |
别名和识别编码
| Chemical Name | (R)-3-(3-(4-Fluorophenylsulfonamido)-3,4-Dihydro-1H-Carbazol-9(2H)-Yl)Propanoic Acid |
|---|---|
| CAS Number | 116649-85-5 |
| Synonym | (+)-(3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid (+)-(3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid BAY u3405 (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic Acid 3-(4-fluorophenylsulfonamido)-1,2,3,4-tetrahydro-9-carbazole propanoic acid BAY u 3405 BAY u 3406 BAY u-3405 BAY u3405 BAY-u 3405 Baynas Ramatroban ramatroban |
| MDL Number | MFCD00887606 |
| Chemical Name Translation | (R)-3-(3-(4-氟苯基磺酰胺基)-3,4-二氢-1H-咔唑-9(2H)-基)丙酸 |
| PubChem Substance ID | 123879 |
| InChI | InChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1 |
| LabNetwork Molecule ID | LN00196684 |
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信息真实价格透明
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分类
- Pharmaceuticals
- {SNA} Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Bayer, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Lipids in Cell Signaling, Other
- Intermediates & Fine Chemicals
- {SNA} Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Bayer, Bioactive Small Molecule Alphabetical Index,
产品应用
- A thromboxane receptor antagonist for use in the treatment of coronary artery disease.
相关文献及参考
- [2]. Sugimoto H, et al. An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D 2 -induced eosinophil migration in vitro. J Pharmacol Exp Ther. 2003 Apr;305(1):347-52.
- [3]. Haba R, et al. Central CRTH2, a second prostaglandin D 2 receptor, mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model. J Neurosci. 2014 Feb 12;34(7):2514-23.
- Rahman, M., et al.: Int. Immunopharmacol., 6, 1736 (2006),
- [1]. Stearns BA, et al. Novel tricyclic antagonists of the prostaglandin D 2 receptor DP2 with efficacy in a murine modelof allergic rhinitis. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51.
- [1]. Stearns BA, et al. Novel tricyclic antagonists of the prostaglandin D 2 receptor DP2 with efficacy in a murine modelof allergic rhinitis. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51.
- [2]. Sugimoto H, et al. An orally bioavailable small molecule antagonist
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312
- P302+P352
- P304+P340
- P305+P351+P338
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P330 Rinse mouth. 漱口
- P332+P313
- P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H302 Harmful if swallowed 吞食有害
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
