Imipramine Hydrochloride 丙咪嗪盐酸盐
CAS 113-52-0 MFCD00012669
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, I, 分析/色谱
- {SNA} Alphabetical Index of Analytical Standards,
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards I - K, Pharmaceutical Standards,
- {SNA} Analytical Standards, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards I - K, 分析/色谱
- {SNA} Analytical Standards, Chromatography, EP Standards,
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards,
- {SNA} Analytical Standards,
产品应用
- Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters. Has little effect on the dopamine transporter.
相关文献及参考
- Wood, M.D., et al.: Neuropharmacology, 26, 1081 (1987),
- Casis, O., et al.: J. Cardiovasc. Pharmacol., 32, 521 (1998),
- Linner, L., et al.: Biol. Psychiatry, 46, 766 (1999),
- Short: IV/8A Title: Enthalpies of Fusion and Transition of Organic Compounds Author: Zhang, Z.-Y.; Frenkel, M.; March, K.N.; Wilhoit, R.C. Editor: Marsh, K.N. Source: Landolt-Börnstein, New Series Volume: IV/8A Year: 1995 Keyword: organic compounds; enthaly of fusion; melting point; phase transition ISBN: 3-540-58854-X ISBN: 978-3-540-58854-2 Internet Resource: DOI:10.1007/b55145 RefComment: VIII, 588 pages.
- Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
- R22 Harmful if swallowed 吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
- S24 Avoid contact with skin 避免皮肤接触;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
- S33 Take precautionary measures against static discharges 对静电采取预防措施;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S36 Wear suitable protective clothing 穿戴适当的防护服;
- S7 Keep container tightly closed 保存在严格密闭容器中;
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 217 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,391,1971
{hazard_c
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 78 mg/kg TOXIC EFFECTS : Cardiac - other changes REFERENCE : THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 20,67,1965
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Vascular - BP lowering not characterized in autonomic section REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 22,539,1984
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 15 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Cardiac - other changes Kidney, Ureter, Bladder - other changes REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/ye
TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Unreported TEST SYSTEM : Insect - not otherwise specified DOSE/DURATION : 10 gm/L REFERENCE : JCLBA3 Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10003) V.12- 1962- Volume(issue)/page/year: 47,182a,1970
TYPE OF TEST : Specific locus test ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 10 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 260,99,1991
TYPE OF TEST : DNA inhibition ROUTE OF EXPOSURE : Unreported TEST SYSTEM : Insect - not otherwise specified DOSE/DURATION : 10 gm/L REFERENCE : JCLBA3 Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10003) V.12- 1962- Volume(issue)/page/year: 47,182a,1970
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 800 mg/kg SEX/DURATION : female 1-16 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 15,1222,1965
{hazard_c
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 65 mg/kg SEX/DURATION : female 8-20 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - biochemical and metabolic REFERENCE : TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 6,173,1986
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 130 mg/kg SEX/DURATION : female 8-20 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system REFERENCE : TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 6,173,1986
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE : 165 mg/kg SEX/DURATION : female 3-18 day(s) after conception TOX
- P301+P312+P330
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
其他信息
- 药理作用:盐酸丙咪嗪(113-52-0)为三环类抗抑郁药,适用于治疗迟缓性的内因性抑郁症。主要作用在于阻断中枢神经系统对去甲肾上腺素和5-羟色胺这二种神经递质的再摄取,从而使突触间隙中这二种神经递质浓度增高,发挥抗抑郁作用。盐酸丙咪嗪(113-52-0)还有抗胆碱,抗1肾上腺素受体及抗H1组胺受体作用,但对多巴胺受体影响甚小。
- 方法一:10,11-二氢-5-二苯并[b,f]氮杂卓(见14230)与甲苯、钠氨一起加热回流1h,冷至40-50℃,滴加1-氯-3-二甲氨基丙烷,再回流16h。冷却,过滤,滤液水洗层,取甲苯层减压蒸馏,回收甲苯后,收集210-230℃(0.67kPa)馏分,得米帕明碱,最后经成盐而得成品。
- 上游原料:环己亚胺 --> 二苯 --> 米帕明
- MOL 文件:113-52-0.mol
- 用途一:镇静安眠性抗组织胺及抗抑郁药,治疗精神抑郁症及小儿遗尿症。
- 图谱信息:盐酸丙咪嗪(113-52-0)质谱(MS) 盐酸丙咪嗪(113-52-0)红外图谱(IR1)
- EPA Substance Registry System:113-52-0(EPA Substance)
- color:white
- 质量标准:中国药典2000;BP2003;EP4;JP14;USP27