Imipramine Hydrochloride 丙咪嗪盐酸盐

CAS 113-52-0 MFCD00012669

化学结构图

113-52-0
SMILES: CN(C)CCCN1c2ccccc2CCc2ccccc21.Cl

化学属性

Mol. FormulaC19H25ClN2
Mol. Weight317
TSCAYes
Melting Point171.0 to 175.0 deg-C
Appearance crystalline 白色或类白色结晶性粉末,无臭或几乎无臭,遇光渐变色。
SolubilityH2O: 50 mg/mL

别名和识别编码

Chemical NameImipramine Hydrochloride
CAS Number113-52-0
Synonym 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydro Chimoreptin 10,11-DIHYDRO-N,N-DIMETHYL-DIBENZ[B,F]AZEPINE-5-PROPANAMINE HYDROCHLORIDE 10,11-DIHYDRO-N,N-DIMETHYL-5H-DIBENZ[B,F]AZEPINE-5-PROPANAMINE HYDROCHLORIDE {Chemi Chrytemin {Chemical {hazar de 丙咪嗪盐酸 IMIPRAMINE HYDROCHLORIDE chrytemin antideprinhydrochloride 5H-dibenz[b,f ]azepine, 5-[3-(dimethylamino)propyl]-10,11-di N-(γ-dimethylaminopropyl)imin LABOTEST-BB LT00452014 dynazina 5-(3-dimethylaminopropyl)-10,11-dihydro-5h-dibenz(b,f)azepinehydrochloride 咪帕明 f)azepine,5-(3-(dimethylamino)propyl)-10,11-dihydro-5h-dibenz(monohydrochloride {uni_ham 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f ]azepine-5-propanamine, monohydrochloride Deprinol G-22355 N-(3-dimethylaminopropyl)iminodibenzyl hydrochloride {u 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(dimethylamino)propyl)-, 10,11-Dihydro-5-(3-(dimethylamino)propyl)-5H-dibenz[b,f]azepine hydrochloride 盐酸丙咪嗪 N,N-二甲基-10,11-二氢-5H-二苯并[b,f]氮杂卓-5-丙胺盐酸盐 cocapimipramine25 Imipramine hydrochloride 10,11-Dihydro-N,N-dimithyl-5,H-dibenz[b,f]azepine-5-pro 10,11-Dihydro-N,N-dim {Che 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine Hydrochloride IMIPRA chimoreptin imizine f)azepine,5-(3-(dimethylamino)propyl)-10,11-dihydro-5h-dibenz(monohydrochl teperine efuranol 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride 5-[3-(Dime {Chemicalbo
MDL NumberMFCD00012669
PubChem Substance ID253661339
EC Number204-030-7
Merck Number4920
Chemical Name Translation丙咪嗪盐酸盐
Wiswesser Line NotationT C676 BN&T&J B3N1&1 &GH
LabNetwork Molecule IDLN00244612
Reaxys-RN3576963
InChIInChI=1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H
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分类

  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, I, 分析/色谱
  • {SNA} Alphabetical Index of Analytical Standards,
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards I - K, Pharmaceutical Standards,
  • {SNA} Analytical Standards, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards I - K, 分析/色谱
  • {SNA} Analytical Standards, Chromatography, EP Standards,
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards,
  • {SNA} Analytical Standards,

产品应用

  • Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters. Has little effect on the dopamine transporter.

相关文献及参考

  • Wood, M.D., et al.: Neuropharmacology, 26, 1081 (1987),
  • Casis, O., et al.: J. Cardiovasc. Pharmacol., 32, 521 (1998),
  • Linner, L., et al.: Biol. Psychiatry, 46, 766 (1999),
  • Short: IV/8A Title: Enthalpies of Fusion and Transition of Organic Compounds Author: Zhang, Z.-Y.; Frenkel, M.; March, K.N.; Wilhoit, R.C. Editor: Marsh, K.N. Source: Landolt-Börnstein, New Series Volume: IV/8A Year: 1995 Keyword: organic compounds; enthaly of fusion; melting point; phase transition ISBN: 3-540-58854-X ISBN: 978-3-540-58854-2 Internet Resource: DOI:10.1007/b55145 RefComment: VIII, 588 pages.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

GHS Symbol
Hazard statements
  • H302 Harmful if swallowed 吞食有害
WGK Germany3
Signal word Warning
Hazard Codes Xn
Risk Statements
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
RTECSHO1925000
Safety Statements
  • S24 Avoid contact with skin 避免皮肤接触;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S33 Take precautionary measures against static discharges 对静电采取预防措施;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S7 Keep container tightly closed 保存在严格密闭容器中;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Storage condition 2-8°C
UN Number UN 1230 3/PG 2
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 217 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 21,391,1971

{hazard_c

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 78 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 20,67,1965

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 22,539,1984

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Cardiac - other changes
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/ye

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 10 gm/L
REFERENCE :
   JCLBA3 Journal of Cell Biology.  (Rockefeller Univ. Press, 1230 York Ave.,
   New York, NY 10003) V.12-    1962-  Volume(issue)/page/year: 47,182a,1970

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 260,99,1991

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 10 gm/L
REFERENCE :
   JCLBA3 Journal of Cell Biology.  (Rockefeller Univ. Press, 1230 York Ave.,
   New York, NY 10003) V.12-    1962-  Volume(issue)/page/year: 47,182a,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 800 mg/kg
SEX/DURATION            : female 1-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 15,1222,1965

{hazard_c

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 65 mg/kg
SEX/DURATION            : female 8-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   6,173,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 130 mg/kg
SEX/DURATION            : female 8-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   6,173,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 165 mg/kg
SEX/DURATION            : female 3-18 day(s) after conception
TOX

Precautionary statements
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

其他信息

  • 药理作用:盐酸丙咪嗪(113-52-0)为三环类抗抑郁药,适用于治疗迟缓性的内因性抑郁症。主要作用在于阻断中枢神经系统对去甲肾上腺素和5-羟色胺这二种神经递质的再摄取,从而使突触间隙中这二种神经递质浓度增高,发挥抗抑郁作用。盐酸丙咪嗪(113-52-0)还有抗胆碱,抗1肾上腺素受体及抗H1组胺受体作用,但对多巴胺受体影响甚小。
  • 方法一:10,11-二氢-5-二苯并[b,f]氮杂卓(见14230)与甲苯、钠氨一起加热回流1h,冷至40-50℃,滴加1-氯-3-二甲氨基丙烷,再回流16h。冷却,过滤,滤液水洗层,取甲苯层减压蒸馏,回收甲苯后,收集210-230℃(0.67kPa)馏分,得米帕明碱,最后经成盐而得成品。
  • 上游原料:环己亚胺 --> 二苯 --> 米帕明
  • MOL 文件:113-52-0.mol
  • 用途一:镇静安眠性抗组织胺及抗抑郁药,治疗精神抑郁症及小儿遗尿症。
  • 图谱信息:盐酸丙咪嗪(113-52-0)质谱(MS) 盐酸丙咪嗪(113-52-0)红外图谱(IR1)
  • EPA Substance Registry System:113-52-0(EPA Substance)
  • color:white
  • 质量标准:中国药典2000;BP2003;EP4;JP14;USP27

系列性分类


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