N-Methyl-4-(4-(3-(trifluoromethyl)benzamido)phenoxy)picolinamide N-甲基-4-(4-(3-(三氟甲基)苯甲酰氨基)苯氧基)吡啶-2-甲酰胺
CAS 1125780-41-7 MFCD20261423
化学结构图
SMILES: CNC(=O)c1cc(Oc2ccc(NC(=O)c3cccc(C(F)(F)F)c3)cc2)ccn1
化学属性
| Mol. Weight | 415.36525 |
|---|---|
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | N-Methyl-4-(4-(3-(trifluoromethyl)benzamido)phenoxy)picolinamide |
|---|---|
| Formula | C21H16F3N3O3 |
| Synonym | SKLB610; SKLB 610; SKLB-610. |
| IUPAC Name | N-methyl-4-(4-(3-(trifluoromethyl)benzamido)phenoxy)picolinamide |
| InChIKey | WACDHHMEVMSODJ-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H16F3N3O3/c1-25-20(29)18-12-17(9-10-26-18)30-16-7-5-15(6-8-16)27-19(28)13-3-2-4-14(11-13)21(22,23)24/h2-12H,1H3,(H,25,29)(H,27,28) |
| Canonical SMILES | O=C(NC)C1=NC=CC(OC2=CC=C(NC(C3=CC=CC(C(F)(F)F)=C3)=O)C=C2)=C1 |
| Chemical Name Translation | N-甲基-4-(4-(3-(三氟甲基)苯甲酰氨基)苯氧基)吡啶-2-甲酰胺 |
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产品应用
- SKLB610 is a VEGFR inhibitor that potently suppresses human tumor angiogenesis. SKLB610 inhibited angiogenesis-related tyrosine kinase VEGFR2, fibroblast growth factor receptor 2 (FGFR2) and platelet-derived growth factor receptor (PDGFR) at rate of 97%, 65% and 55%, respectively, at concentration of 10μM in biochemical kinase assays. SKLB610 exhibited its antitumor activity as a multi-targeted inhibitor with more potent inhibition of VEGFR2 activity. Its potential to be a candidate of anticancer agent is worth being further investigated.
