CAS 110-91-8 MFCD00005972-Morpholine 吗啉 TAO{mole}

Morpholine 吗啉

CAS 110-91-8 MFCD00005972

化学结构图

SMILES: C1COCCN1

化学属性

Mol. Formula	C4H9NO
Mol. Weight	87.12
Refractive index	1.4520 to 1.4560
Boiling Point	129
Density	0.996
Melting Point	-7--5
Flash Point	35.56°C
TSCA	Yes
Autoignition Point	590 °F
Vapor Density	3 (vs air)
Vapor Pressure	31 mmHg ( 38 °C)
Solubility	与水混溶，可混溶于多数有机溶剂。
Stability	易吸潮

别名和识别编码

Chemical Name	Morpholine
Synonym	Morpholine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
CAS Number	110-91-8
PubChem Substance ID	8083
EC Number	203-815-1
Beilstein Registry Number	27,5
MDL Number	MFCD00005972
Reaxys-RN	102549
Merck Number	6277
Chemical Name Translation	吗啉
Wiswesser Line Notation	T6M DOTJ
LabNetwork Molecule ID	LN00193625
InChI	InChI=1S/C4H9NO/c1-3-6-4-2-5-1/h5H,1-4H2
Canonical SMILES	N1CCOCC1

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产品应用

吗啉与无机酸反应生成盐，与有机酸反应生成盐或酰胺。可进行烷基化反应，还可以与环氧乙烷、酮反应或进行Willgerodt反应。

安全信息

GHS Symbol

WGK Germany2

Hazard Codes C

Hazard statements

H226 Flammable liquid and vapour 易燃液体和蒸气
H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H332 Harmful if inhaled 吸入有害
H312 Harmful in contact with skin 皮肤接触有害
H302 Harmful if swallowed 吞食有害
H311+H331

Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSQD6475000

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P303+P361+P353
P201 Obtain special instructions before use. 使用前获取专门指示。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P337+P313
P403+P233
P305+P351+P338+P310
P301+P330+P331+P310

Signal word

UN Number UN2054

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R10 Flammable 易燃
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R34 Causes burns 会导致灼伤

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S1/2 None 上锁保管并避免儿童触及；
S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light Store at R.T. {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, prot

Packing GroupI

Hazard Class8/3

Warnings 危化品目录(2015)

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2560 mg/kg/Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - bronchiogenic carcinoma
   Liver - tumors
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 44(8),15,1979

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 12000 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   Toxicology of New Industrial Chemical Substances.  For English translation,
   see TNICS*.  (Izdatel'stvo Meditsina, Moscow, USSR)  No.1-    1961-
   Volume(issue)/page/year: 14,90,1975

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1320

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 458 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4576951

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 413 mg/kg
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volume(issue)/page/year: 2,1055,1949

TYPE OF TEST            : LD50 - Lethal dose, 50 percent

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 1220 mg/kg
TOXIC EFFECTS :
   Details of toxic

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 125 mg/L
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-0779-0294

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1 uL/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 4,390,1982

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 160 mg/L
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-0779-0294

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1 gm/L
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-0779-0294

Restrict 危险品

其他信息

外观性质:无色油状液体，有氨味。
用途六:1,4-氧氮六环（110-91-8）主要应用于生产橡胶促进剂、合成病毒灵、布烙芬、咳必定等多种药物，在油漆、农药、增白剂、溶剂等方面也有广泛用途。还可用于制造N-甲基吗啉、N-乙基吗啉等多种中间体。
刺激数据:皮肤-兔子 995 毫克/24小时重度; 眼睛-兔子 2 毫克重度
TCI Shanghai:吗啉 Morpholine,>;99.0%(GC)(110-91-8)
上游原料:氢氧化钠 --> 硫酸 --> 氨 --> 1,4-二氧六环 --> 氢 --> 4-氯苯甲醛 --> 二乙醇胺 --> 二乙二醇
具有吸湿性和特殊的胺味，能以任何比例与水互溶，易溶于芳烃、醇、酮类、醚类和有机溶剂中，微溶于矿物油和脂肪族烃中，有轻微毒性。能随水蒸气挥发。
方法二:由二乙醇胺经硫酸脱水环合而得。将二乙醇胺加入水反应锅内，在60℃以下滴加硫酸，加毕，升温于185-195℃，保温30min。冷至60℃以下，滴加氢氧化钠液至pH=11，冷却，过滤，滤液精馏，收集130℃以下馏分，精吗啉含量可达99.5%以上。该法原料易得，目前已成为世界生产吗啉的主要方法。由二噁烷与氨气相催化反应而可制得吗啉。
图谱信息:1,4-氧氮六环(110-91-8)Raman光谱 1,4-氧氮六环(110-91-8)红外图谱(IR1) 1,4-氧氮六环(110-91-8)核磁图( 1 HNMR) 1,4-氧氮六环(110-91-8)核磁图( 13 CNMR) 1,4-氧氮六环(110-91-8)质谱(MS)
参考质量标准:FCC，1996 含量 ≥99.0% 馏程 126.0～130.0℃ 重金属(以Pb计) ≤1mg/kg 折射率(n D 20 ) 1.454～1.455 相对密度(d 25 25 ) 0.994～0.997
灭火剂:干粉, 二氧化碳, 泡沫, 雾状水
含量分析:取0.1%溴甲酚绿的甲醇液4份，0.1%甲基红钠盐的水溶液1份，混合，作为混合指示剂。一250m1烧瓶中盛水50m1，加上述混合指示剂0.4ml，逐滴加入0.1moI/L盐酸，中和至绿色。准确称取试样1.4～1.6g，加入该烧瓶，混匀。用0.5mol/L盐酸滴定至绿色。每ml，0.5mol/L盐酸相当于C 4 H 9 NO 43.56mg。
用途一:促进剂NOBS的主要原料,有作分析试剂及树脂、蜡类、虫胶等的溶剂 ,用于生产硫酸钠.水玻璃和群青等。还用于制造玻璃.造纸.洗涤剂.肥皂.染料.合成纤维.制革.医药和陶瓷等行业。分析试剂，如氮的测定，脱水剂。
产品特性:吗啉又称为1,4-氧氮杂环己烷，常温下是一种无色油状液体，能与水、丙酮、醚、苯、醇、乙二醇和油类混溶，有吸湿性和氨味，可随水蒸汽挥发。吗啉含有仲胺基团，具有仲胺基团的所有典型反应特征。与无机酸反应生成盐，与有机酸反应生成盐或酰胺，可进行烷基化反应，还可以与环氧乙烷、酮反应或进行Willgerodt反应。由于吗啉所具有的独特的化学性质，使其成为当前具有重要商业用途的精细石油化工产品之一,可用于制备NOBS、DTOS和MDS等橡胶硫化促进剂、防锈剂、防腐蚀剂、清洁剂、除垢剂、止痛药、局部麻醉剂、镇静剂、呼吸系统与血管兴奋剂、表面活化剂、光学漂白剂、水果保鲜剂、纺织印染助剂等，在橡胶、医药、农药、染料、涂料等行业有着广泛的用途，医药方面用于生产吗啉胍、病毒灵、布洛芬、咳必定、萘普生、二氯苯胺、苯乙酸钠等多种重要药物。吗啉的生产方法主要有DEA法(二乙醇胺法)和DEG法(二甘
Sigma Aldrich:110-91-8(sigmaaldrich)
毒性:LD 50 1050mg/kg(大鼠，经口)。
类别:易燃液体
毒性防护:蒸气刺激皮肤及眼粘膜，引起呼吸困难，具有全身毒性作用，可引起肝，肾变性及坏死性病变。人体在43mg/L浓度下，作用1分钟，对鼻粘膜产生强烈
用途四:吗啉是杀菌剂烯酰吗啉和氟吗啉及有机磷杀虫剂茂硫磷的中间体。
下游
职业标准:TLV-TWA 70