N-Methylmorpholine N-甲基吗啡啉

CAS 109-02-4 MFCD00006175

化学结构图

109-02-4
SMILES: CN1CCOCC1

化学属性

Mol. FormulaC5H11NO
Mol. Weight101
Density0.92
Refractive index1.4340 to 1.4370
Vapor Density>;1 (vs air)
Boiling Point115-116
Vapor Pressure18 mmHg ( 20 °C)
Melting Point-66
Flash Point18°C(lit.)
TSCAYes
Solubility与水混溶，溶于苯。
Stability对光敏感
pH:A

别名和识别编码

Chemical NameN-Methylmorpholine
CAS Number109-02-4
EC Number203-640-0
Beilstein Registry Number102719
MDL NumberMFCD00006175
Synonym 4-METHYL-1-OXA-4-AZACYCLOHEXANE 4-METHYLMORPHOLINE 4-METHYLMORPHOLINE REAGENTPLUS(TM) 9& 4-METHYLMORPHOLINE, FOR PROTEIN SEQUENCE ANALYSIS 4-METHYLMORPHOLINE, REDISTILLED, 99.5+% 4-Methyl-1-oxa-4-azacyclohexane; N-Methylmorpholine 4-Methylmorf 4-Methylmorpholine 4-methyl-morpholin 4-methyl-morpholine 4-methyl-morpholinium 4-methylmorpholine 4-甲基吗啉 4-甲基吗啉; 4-甲基吗啡啉; N-甲基吗啡啉; 1,4-氧氮杂环庚烷 AKOS 89985 LUPRAGEN(R) N 105 Lupragen N 105 Lupragen® N 105 Methylmorpholine Morpholine,4-methyl- N-METHYLMORPHOLINE N-Methyl-morpholine N-Methylmorpholine N-甲基吗啡啉 NMM Texacat NMM p-Methyl morpholine
PubChem Substance ID7972
Merck Number6277
Chemical Name TranslationN-甲基吗啡啉
Reaxys-RN102719
Wiswesser Line NotationT6N DOTJ A1
LabNetwork Molecule IDLN00195500
InChIInChI=1S/C5H11NO/c1-6-2-4-7-5-3-6/h2-5H2,1H3
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分类

  • {uni_hamburg} no charge; oxygen heterocycle; nitrogen heterocycle; alicycle; 6RingOnly; 6ring; ether; 1fragment
  • {Chemicalbook} 农药中间体: 植物生长调节剂中间体
  • {SNA} Protein Sequencing, Protein Structural
  • {SNA} Molecular Biology, Protein Sequencing, Protein Structural Analysis, Proteomics, Reagents for Protein Sequencing
  • {SNA} Building Blocks, C4 to C10, Chemical Synthesis, Heterocyclic Building Blocks, Morpholines/Thiomorpholines
  • {SNA} Protein Sequencing, Reagents for Protein Sequencing, 分子生物学, 蛋白质组学, 蛋白质结构分析
  • {SNA} Building Blocks, C4 to C10, Chemical Synthesis, Essential Chemicals, Heterocyclic Building Blocks, Inorganic Salts, Solutions and Reagents, Morpholines/Thiomorpholines, Reagent Plus,

产品应用

  • 萃取溶剂，催化剂，腐蚀抑制剂、分析试剂及药品制造等

相关文献及参考

  • Merck:14,6277
  • Short: III/20a
  • Short: II/14a
  • Merck:14,6277 Beilstein:27,6
  • Short: III/35B
  • Widely used base in peptide chemistry, milder than triethylamine. Recommended for the avoidance of racemization in the mixed anhydride method of coupling: J. Am. Chem. Soc., 88, 1338 (1966); 89, 5012 (1967). Also preferred in many cases for the formation of active esters or the neutralization of acid salts. For peptide reagents, see Appendix 6.

安全信息

Signal word Danger
GHS Symbol
WGK Germany1
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R11 Highly flammable 非常易燃
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P211 Do not spray on an open flame or other ignition source.? 不要喷洒在明火或其他点火源。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P303+P361+P353
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
  • H302+H312+H332
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSQE5775000
Packing GroupII
UN Number 2535 UN 2535 3/PG 2 UN2535
Hazard Codes 3 F,C
Storage condition Store at RT. 密封阴凉避光保存。
Hazard Class3/8
Warnings 危化品目录(2015) 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 1917 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 39(4),86,1974

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2000 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 31,60,1949

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25200 mg/m3/2H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   Toxicology of New Industrial Chemical Substances.  For English translation,
   see T

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1960 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,85,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 perce

Restrict 危险品

其他信息

  • 用途一:用作溶剂、催化剂、乳化剂、有机合成中间体等
  • 用途二:用
  • Alfa Aesar:4-甲基吗啉,99% 4-Methylmorpholine, 99%(109-02-4)
  • 职业标准:TWA 20 毫克/ 立方米; STEL 40 毫克/ 立方米
  • 毒性分级:中毒
  • 用途四:用于萃取溶剂、氯烃类的稳定剂、阻蚀剂、催化剂、药物的生产。
  • 用途六:萃取溶剂，催化剂，腐蚀抑制剂、分析试剂及药品制造等
  • MSDS 信息:N-甲基吗啉(109-02-4).msds
  • {Chemi
  • 灭火剂:干粉、干砂、二氧化碳、泡沫、1211灭火剂
  • 上游原料:氨 --> 甲醛 --> 甲酸 --> 一甲胺 --> 1,4-氧氮六环 --> 二乙二醇 --> 乙醛酸 --> 二氯乙醚
  • 检测方法:GC,NMR
  • 下游产品:1-叔丁氧羰基-4-氨甲基哌啶 --> 1-Boc-3-氨甲基哌啶 --> 3-氨基-5-氟吡啶 --> 盐酸阿扎司琼 --> 扎鲁司特 --> 头孢匹胺 --> 替尼达普 --> 氧化-4-甲基吗啉一水合物 --> 福辛普利 --> 4-(4,6-二甲氧基三嗪-2-基)-4-甲基吗啉盐酸盐 --> 贝那普利 --> 阿拉普利 --> 1-羟基苯并三唑一水物
  • {Chemicalb
  • 图谱信息:N-甲基吗啡啉(109-02-4)红外图谱(IR1) N-甲基吗啡啉(109-02-4)红外图谱(IR2) N-甲基吗啡啉(109-02-4)质谱(MS) N-甲基吗啡啉(109-02-4)核磁图( 13 CNMR) N-甲基吗啡啉(109-02-4)Raman光谱
  • 方法二:由吗啉与甲醛、甲酸反应而得。将甲醛慢慢加入吗啉中，在搅拌下滴加甲酸，反应自动回流并放出二氧化碳。加完甲酸后，加热回流4-5h。冷却后加入氢氧化钠立即蒸馏，收集小于99℃的全部馏分，加入氢氧化钠至饱和，冷却分出油层，干燥，分馏，收集114.5-117℃馏分即为成品。另一种方法以二氯乙醚、一甲胺水溶液、液碱等搂原料，一步法合成，流程短，设备简单，工艺条件温和，投次少，产品收率高，质量好。
  • {Ch
  • Acros Organics:N-甲基吗啉 N-Methylmorpholine, 99%(109-02-4)
  • 类别:易燃液体
  • Sigma Aldrich:109-02-4(sigmaaldrich)
  • 刺激数据:眼睛- 兔子 920微克 重度; 皮肤- 兔子 460 毫克 轻度
  • 方法一:其制备方法是在吗啉中慢慢滴加甲醛，于搅拌下滴加甲酸反应，自动回流，并放出二氧化碳。加完甲酸后，加热回流4～5h，冷却后加入氢氧化钠立即蒸馏，收集沸点99℃前的全部馏分
  • N-甲基吗啡啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80084427 N-甲基吗啉;4-甲基吗啉 250ml 44元 2011/04/16 M0370 4-甲基吗啉 4-Methylmorpholine 25ML 175元 2011/04/16 M0370 4-甲基吗啉 4-Methylmorpholine 500ML 355元
  • 储运特性:库房通风低温干燥; 与
  • 蒸气密度:>;1 (vs air)
  • 用途五:在聚氨酯行业，N-甲基吗啉（109-02-4）用作聚酯型聚氨酯软块泡的催化剂。N-甲基吗啉（109-02-4）还用作溶剂、催化剂、腐蚀抑制剂等，也用于橡胶促进剂和其他精细化学品的合成，用作合成氨基苄青霉素和基苄基青霉素的催化剂。用双氧水氧化N-甲基吗啉可制造N-甲基氧化吗啉。
  • 用途三:N-甲基吗啉是植物生长调节剂调节安的中间体。
  • 有氨的气味。对空气敏感。能与水、乙醇、苯和乙醚混溶，水中溶解度:>500 g/L (20°C)。易燃。有腐蚀性、微毒、有刺激性气味。
  • 蒸气压:18 mm Hg ( 20 °C)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Indazoles 吲唑
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Isoxazoles 异恶唑
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Morpholines/Thiomorpholines 吗啉/硫吗啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Morpholines/Thiomorpholines 吗啉/硫吗啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Life Science 生命科学
  2. Proteomics 蛋白质组学
  3. Protein Structural Analysis - Proteomics
  4. Protein Sequencing - Protein Structural Analysis
  5. Reagents for Protein Sequencing - Protein Sequencing
  1. Life Science 生命科学
  2. Proteomics 蛋白质组学
  3. Protein Structural Analysis - Proteomics
  4. Protein Sequencing - Protein Structural Analysis
  5. Reagents for Protein Sequencing - Protein Sequencing
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Morpholines/Thiomorpholines 吗啉/硫吗啉
  5. C4 to C10 - Morpholines/Thiomorpholines
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrazoles 吡唑