Y11
CAS 1086639-59-9 MFCD186639599
化学结构图
SMILES: OCC[N+]12C[N@]3C[N@](C1)C[N@@](C2)C3.[Br-]
化学属性
| Mol. Weight | 265.15078 |
|---|---|
| Mol. Formula | C8H17BrN4O |
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| CAS Number | 1086639-59-9 |
|---|---|
| Chemical Name | Y11 |
| Synonym | 1-(2-Hydroxyethyl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane Bromide Y11; Y-11; Y 11 |
| Chemical Name Translation | |
| Formula | C8H17BrN4O |
| IUPAC Name | (3r,5r,7r)-1-(2-hydroxyethyl)-1,3,5,7-tetraazaadamantan-1-ium bromide. |
| Canonical SMILES | OCC[N+]12C[N@]3C[N@](C2)C[N@](C3)C1.[Br-] |
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分类
- Heterocycles
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- Y11 is a small molecule inhibitor targeting Y397 site of FAK. Y11 significantly and specifically decreased FAK autophosphorylation, directly bound to the N-terminal domain of FAK. In addition, Y11 decreased Y397-FAK autophosphorylation, inhibited viability and clonogenicity of colon SW620 and breast BT474 cancer cells and increased detachment and apoptosis in vitro. Moreover, Y11 significantly decreased tumor growth in the colon cancer cell mouse xenograft model. Finally, tumors from the Y11-treated mice demonstrated decreased Y397-FAK autophosphorylation and activation of poly (ADP ribose) polymerase and caspase-3.
相关文献及参考
- Xing, Z., et al.: Mol. Biol. Cell, 5, 413 (1994),
- Halder, J., et al.: Clin. Cancer Res., 11, 8829 (2005),
- Beierle, E., et al.: J. Biol. Chem., 282, 12503 (2007),
